RELIGRAST300 MCG PFS

About

Granulocyte colony-stimulating factor (G-CSF) is a recombinant human protein that plays a crucial role in regulating the production, maturation, and release of functional neutrophils from the bone marrow. This medication, a biosimilar to filgrastim, is primarily indicated to decrease the incidence of infection, particularly febrile neutropenia, in patients with nonmyeloid malignancies who are receiving myelosuppressive anti-cancer drugs associated with a significant incidence of febrile neutropenia. It achieves this by binding to specific receptors on myeloid progenitor cells, stimulating their proliferation and differentiation into mature neutrophils. Beyond chemotherapy-induced neutropenia, it is also utilized in the treatment of severe chronic neutropenia, for the mobilization of peripheral blood progenitor cells for autologous or allogeneic transplantation, and to accelerate neutrophil recovery following bone marrow transplantation. Its therapeutic action helps to bolster the body's immune defense during periods of vulnerability.

Uses

• Reduce incidence of febrile neutropenia in chemotherapy.
• Treat severe chronic neutropenia.
• Mobilize peripheral blood progenitor cells.
• Support neutrophil recovery after bone marrow transplant.

Directions For Use

Administer subcutaneously or intravenously as directed by a healthcare professional. Dosage is based on body weight and clinical condition.

Benefits

• Reduces risk of serious infections.
• Accelerates neutrophil recovery.
• Allows for timely chemotherapy cycles.
• Improves quality of life for neutropenic patients.
• Supports stem cell collection for transplantation.
• Enhances immune system function during critical periods.

Side Effects

• Bone pain
• Muscle aches
• Headache
• Fatigue
• Nausea
• Vomiting
• Diarrhea
• Injection site reactions
• Splenomegaly (rare)
• Allergic reactions (rare)
• Acute respiratory distress syndrome (rare)
• Glomerulonephritis (rare)

Safety Measures

• Alcohol - No specific interaction known; however, excessive alcohol use may impair overall health and immune function.
• Pregnancy - Use only if clearly needed; potential risks to the fetus should be weighed against maternal benefits.
• Breastfeeding - Excretion into breast milk is unknown; caution is advised, and a physician should be consulted.
• Liver - Generally safe; no specific dose adjustment required for mild to moderate hepatic impairment.
• Kidney - Generally safe; no specific dose adjustment required for mild to moderate renal impairment.
• Lung - Use with caution in patients with pre-existing lung conditions; monitor for respiratory symptoms.

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