Endokine 300mcg Injection PFS

About

Endokine 300mcg Injection PFS (Pre-Filled Syringe) contains Filgrastim, a recombinant human granulocyte colony-stimulating factor (G-CSF). Filgrastim is a glycoprotein that regulates the production and release of neutrophils from the bone marrow. It works by binding to specific receptors on hematopoietic stem cells and progenitor cells, stimulating their proliferation, differentiation, and maturation into functional neutrophils. This action is crucial for patients undergoing myelosuppressive chemotherapy, where a significant reduction in white blood cell count (neutropenia) can lead to life-threatening infections.

The pre-filled syringe formulation offers convenience and ease of administration, ensuring accurate dosing. By accelerating neutrophil recovery, Endokine 300mcg helps to reduce the incidence, severity, and duration of neutropenia, thereby minimizing the risk of febrile neutropenia and associated complications. It also enables patients to receive their planned chemotherapy cycles on schedule, which is vital for treatment efficacy. Beyond chemotherapy, it is also used in other conditions involving neutropenia, such as severe chronic neutropenia and for mobilization of peripheral blood progenitor cells for autologous or allogeneic transplantation.

Uses

• Prevention of chemotherapy-induced neutropenia
• Treatment of severe chronic neutropenia
• Mobilization of peripheral blood progenitor cells
• Neutrophil recovery after bone marrow transplantation

Directions For Use

Administered via subcutaneous injection or intravenous infusion by a healthcare professional. Follow prescribed dosage and administration instructions.

Benefits

• Reduces the risk of serious infections
• Shortens the duration of neutropenia
• Allows for on-schedule chemotherapy treatments
• Improves quality of life for cancer patients
• Supports stem cell collection for transplantation
• Enhances immune system recovery

Side Effects

• Bone pain
• Fever
• Fatigue
• Headache
• Nausea
• Diarrhea
• Injection site reactions
• Splenomegaly (enlarged spleen)
• Allergic reactions
• Acute respiratory distress syndrome (rare)
• Capillary leak syndrome (rare)
• Thrombocytopenia (low platelet count)

Safety Measures

• Alcohol - No direct interaction is known, but general health advice to limit alcohol intake during medical treatment applies.
• Pregnancy - Use only if clearly needed and the potential benefits outweigh the risks. Consult a doctor, as animal studies show potential fetal harm.
• Breastfeeding - It is unknown if Filgrastim is excreted in human milk. Exercise caution and consult a doctor before breastfeeding.
• Liver - No specific dose adjustment is generally required for liver impairment, but monitor patient's overall condition.
• Kidney - No specific dose adjustment is generally required for kidney impairment, but monitor patient's overall condition.
• Lung - Rare cases of acute respiratory distress syndrome (ARDS) and pulmonary infiltrates have been reported. Monitor for new or worsening respiratory symptoms.

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