Glioz 100mg Capsule

About

Temozolomide is an oral alkylating agent primarily utilized in the treatment of specific brain tumors, including newly diagnosed glioblastoma multiforme and refractory anaplastic astrocytoma. Its mechanism of action involves the alkylation of DNA, which leads to DNA damage and subsequent inhibition of cancer cell proliferation. By interfering with the DNA replication and repair processes, temozolomide induces cell cycle arrest and apoptosis in rapidly dividing tumor cells. This cytotoxic effect is particularly valuable in managing glioblastoma multiforme when administered concurrently with radiotherapy and as subsequent maintenance therapy. Furthermore, its lipophilic nature allows it to effectively cross the blood-brain barrier, making it a crucial systemic treatment option for central nervous system malignancies. The drug's ability to target tumor cells within the brain contributes significantly to its efficacy in improving patient outcomes in these challenging cancers.

Uses

• Treatment of newly diagnosed glioblastoma multiforme.
• Management of refractory anaplastic astrocytoma.
• Used in combination with radiation therapy.
• Maintenance therapy for certain brain cancers.

Directions For Use

Take this capsule orally, usually once daily, as directed by your doctor. Swallow whole with a glass of water, preferably on an empty stomach.

Benefits

• Effective against specific brain tumors.
• Can be administered orally, offering convenience.
• Crosses the blood-brain barrier effectively.
• Used in both initial and recurrent disease settings.
• Improves progression-free survival in glioblastoma.
• Part of a standard treatment regimen for certain gliomas.

Side Effects

• Nausea and vomiting
• Fatigue
• Headache
• Constipation
• Loss of appetite
• Hair loss (alopecia)
• Rash
• Myelosuppression (low blood counts)
• Thrombocytopenia (low platelets)
• Neutropenia (low neutrophils)
• Infections
• Liver enzyme elevation

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may worsen side effects like nausea and fatigue, and potentially increase liver strain.
• Pregnancy - Temozolomide is contraindicated in pregnancy due to its genotoxic and teratogenic potential. Effective contraception is required during treatment and for a period after.
• Breastfeeding - Breastfeeding is not recommended during treatment with temozolomide and for a period after, as the drug may pass into breast milk and harm the infant.
• Liver - Use with caution in patients with severe hepatic impairment. Liver function tests should be monitored regularly during treatment.
• Kidney - Use with caution in patients with severe renal impairment. Dosage adjustments may be necessary based on kidney function.
• Lung - Rare cases of interstitial pneumonitis or pulmonary fibrosis have been reported; monitor for new or worsening respiratory symptoms.

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