GLUCRETA TAB

About

GLUCRETA TAB is a combination medication primarily used in the management of type 2 diabetes mellitus. It typically combines two active ingredients: Metformin, a biguanide, and Vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor. Metformin works by decreasing hepatic glucose production, reducing intestinal glucose absorption, and improving insulin sensitivity by increasing peripheral glucose uptake and utilization. Vildagliptin enhances the body's natural ability to control blood glucose levels by increasing the levels of active incretin hormones, GLP-1 and GIP. These hormones stimulate insulin release from the pancreas when blood glucose levels are high and suppress glucagon secretion, thereby reducing glucose production by the liver.

This dual mechanism of action provides comprehensive glycemic control, helping patients achieve target blood sugar levels when diet and exercise alone are insufficient or when monotherapy with Metformin is inadequate. It is an effective option for improving HbA1c and managing hyperglycemia, contributing to better long-term diabetes management and reducing the risk of complications.

Uses

• Management of type 2 diabetes mellitus
• Adjunct to diet and exercise
• When Metformin monotherapy is insufficient
• To improve glycemic control in adults

Directions For Use

Take orally, with meals, as directed by your physician. Do not crush or chew the tablet.

Benefits

• Provides comprehensive glycemic control
• Reduces HbA1c levels effectively
• Improves insulin sensitivity
• Low risk of hypoglycemia
• Supports weight management (Metformin component)
• Convenient combination therapy

Side Effects

• Nausea
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Lactic acidosis (rare, serious)
• Pancreatitis (rare)
• Skin reactions (rash, itching)
• Peripheral edema
• Nasopharyngitis
• Tremor
• Fatigue

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it may increase the risk of lactic acidosis, a serious side effect, especially with the Metformin component.
• Pregnancy - Generally not recommended during pregnancy unless the potential benefits outweigh the risks. Consult your doctor.
• Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk. Consult your doctor.
• Liver - Use with caution in patients with liver impairment. Dose adjustment or avoidance may be necessary.
• Kidney - Contraindicated in severe renal impairment due to the Metformin component. Dose adjustment is required for moderate impairment.
• Lung - No specific direct lung contraindication, but severe respiratory failure can increase the risk of lactic acidosis.

Disclaimer

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