TRESIBA FLETUCH

About

Tresiba (Insulin Degludec) is an ultra-long-acting basal insulin analogue designed for the treatment of diabetes mellitus in adults, adolescents, and children aged 1 year and above. Its unique formulation allows for a duration of action exceeding 42 hours, providing a consistent and stable glucose-lowering effect. This extended duration enables flexible once-daily dosing, where patients can adjust their injection time if needed, without compromising glycemic control. Upon subcutaneous injection, insulin degludec forms soluble multi-hexamers, creating a depot from which the insulin is slowly and continuously released into the bloodstream. This mechanism contributes to its low day-to-day variability and a reduced risk of nocturnal hypoglycemia compared to other basal insulins.

Tresiba is used to establish foundational basal insulin coverage, helping to maintain fasting and between-meal blood glucose levels within target ranges. It can be incorporated into various treatment regimens, either as monotherapy or in combination with rapid-acting insulin, oral antidiabetic agents, or GLP-1 receptor agonists. Patients must receive comprehensive education on proper injection technique, the importance of regular blood glucose monitoring, and how to titrate their dose based on their glucose readings. Regular follow-up with a healthcare professional is vital to monitor for hypoglycemia, manage any potential adverse effects, and ensure the long-term safety and efficacy of diabetes management.

Uses

• Treatment of Type 1 Diabetes Mellitus
• Management of Type 2 Diabetes Mellitus
• Provides ultra-long-acting basal insulin coverage
• Helps maintain stable fasting blood glucose levels

Directions For Use

Inject subcutaneously once daily, at any time of day, but preferably at the same time each day. Rotate injection sites.

Benefits

• Provides ultra-long-acting glucose control (over 42 hours)
• Offers flexible once-daily dosing schedule
• Low day-to-day variability in glucose-lowering effect
• Reduced risk of nocturnal hypoglycemia
• Can be used in various combination therapies
• Helps achieve stable fasting blood glucose levels

Side Effects

• Hypoglycemia (low blood sugar)
• Injection site reactions (pain, redness, swelling)
• Lipodystrophy (fat accumulation or atrophy)
• Weight gain
• Allergic reactions
• Peripheral edema
• Pruritus
• Rash
• Urticaria
• Blurred vision (temporary)
• Diabetic retinopathy worsening (temporary)
• Hypokalemia (low potassium)

Safety Measures

• Alcohol - Alcohol can lower blood sugar and increase the risk of hypoglycemia. Use with caution and monitor glucose levels.
• Pregnancy - Consult a doctor. Insulin requirements may change during pregnancy. Close monitoring is essential.
• Breastfeeding - Generally considered safe, but consult a healthcare provider. Insulin does not pass into breast milk in significant amounts.
• Liver - Use with caution in hepatic impairment; insulin requirements may be altered. Monitor glucose levels closely.
• Kidney - Use with caution in renal impairment; insulin requirements may be altered. Monitor glucose levels closely.
• Lung - No specific contraindications for lung conditions.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.