SITALAMBIC 100 10S

About

SITALAMBIC 100 contains Sitagliptin, an oral antihyperglycemic agent belonging to the dipeptidyl peptidase-4 (DPP-4) inhibitor class. This medication is specifically designed for the treatment of type 2 diabetes mellitus. Sitagliptin works by selectively inhibiting the enzyme DPP-4, which is responsible for the rapid inactivation of incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By preserving the active forms of these incretins, sitagliptin enhances glucose-dependent insulin secretion from the pancreatic beta cells and simultaneously reduces glucagon secretion from the pancreatic alpha cells.

This dual action leads to improved fasting and post-prandial blood glucose levels, contributing to better overall glycemic control. It is typically used as an adjunct to diet and exercise, either as monotherapy or in combination with other antidiabetic agents, to help patients achieve their target HbA1c levels.

Uses

• Treatment of type 2 diabetes mellitus.
• Improvement of glycemic control.
• Used as monotherapy or in combination.
• Adjunct to diet and exercise.

Directions For Use

Take one tablet orally once daily, with or without food, as directed by your healthcare provider.

Benefits

• Effective blood sugar reduction.
• Low risk of hypoglycemia as monotherapy.
• Weight-neutral effect.
• Improved pancreatic beta-cell function.
• Well-tolerated side effect profile.
• Convenient once-daily dosing.

Side Effects

• Headache
• Upper respiratory tract infection
• Nasal congestion
• Sore throat
• Diarrhea
• Nausea
• Abdominal pain
• Joint pain
• Pancreatitis (rare)
• Hypersensitivity reactions (e.g., rash, urticaria)
• Bullous pemphigoid (rare)
• Kidney problems (rare)

Safety Measures

• Alcohol - Moderate alcohol consumption is generally acceptable, but excessive intake should be avoided.
• Pregnancy - Not recommended during pregnancy; use only if potential benefit justifies the potential risk to the fetus.
• Breastfeeding - Not recommended during breastfeeding as it may be excreted in breast milk; consult a doctor.
• Liver - No specific dose adjustment needed for mild to moderate hepatic impairment. Use with caution in severe impairment.
• Kidney - Dose adjustment is required for moderate to severe renal impairment and end-stage renal disease.
• Lung - No specific contraindications or safety notes related to lung conditions.

Disclaimer

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