TRESIBA PENFIL 3ML

About

Tresiba Penfill 3ml contains insulin degludec, a ultra-long-acting basal insulin analogue indicated for the treatment of diabetes mellitus in adults, adolescents, and children aged 1 year and above. Insulin degludec is designed to provide a flat and stable glucose-lowering effect for more than 42 hours, allowing for flexible once-daily dosing. Upon subcutaneous injection, it forms soluble multi-hexamers that create a subcutaneous depot, from which insulin is slowly and continuously absorbed into the circulation. This unique mechanism of action results in a consistent glucose-lowering profile with low day-to-day variability, which can help reduce the risk of nocturnal hypoglycemia compared to other basal insulins.

Tresiba is used to provide foundational basal insulin coverage, helping to maintain fasting and between-meal blood glucose levels within target ranges. It can be used as monotherapy or in combination with rapid-acting insulin, oral antidiabetic agents, or GLP-1 receptor agonists. Patients should be thoroughly instructed on proper injection technique, dose titration based on blood glucose monitoring, and the importance of rotating injection sites to prevent lipodystrophy. Regular consultation with a healthcare professional is crucial to adjust doses, monitor for hypoglycemia, and manage any potential adverse effects, ensuring safe and effective long-term diabetes management.

Uses

• Treatment of Type 1 Diabetes Mellitus
• Management of Type 2 Diabetes Mellitus
• Provides ultra-long-acting basal insulin coverage
• Helps maintain stable fasting blood glucose levels

Directions For Use

Inject subcutaneously once daily, at any time of day, but preferably at the same time each day. Rotate injection sites.

Benefits

• Provides ultra-long-acting glucose control (over 42 hours)
• Offers flexible once-daily dosing schedule
• Low day-to-day variability in glucose-lowering effect
• Reduced risk of nocturnal hypoglycemia
• Can be used in various combination therapies
• Helps achieve stable fasting blood glucose levels

Side Effects

• Hypoglycemia (low blood sugar)
• Injection site reactions (pain, redness, swelling)
• Lipodystrophy (fat accumulation or atrophy)
• Weight gain
• Allergic reactions
• Peripheral edema
• Pruritus
• Rash
• Urticaria
• Blurred vision (temporary)
• Diabetic retinopathy worsening (temporary)
• Hypokalemia (low potassium)

Safety Measures

• Alcohol - Alcohol can lower blood sugar and increase the risk of hypoglycemia. Use with caution and monitor glucose levels.
• Pregnancy - Consult a doctor. Insulin requirements may change during pregnancy. Close monitoring is essential.
• Breastfeeding - Generally considered safe, but consult a healthcare provider. Insulin does not pass into breast milk in significant amounts.
• Liver - Use with caution in hepatic impairment; insulin requirements may be altered. Monitor glucose levels closely.
• Kidney - Use with caution in renal impairment; insulin requirements may be altered. Monitor glucose levels closely.
• Lung - No specific contraindications for lung conditions.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.