Grafeel 300mcg Injection Vial

About

Grafeel 300mcg Injection Vial contains Filgrastim, a recombinant human granulocyte colony-stimulating factor (G-CSF). Filgrastim works by stimulating the production, maturation, and activation of neutrophils, a type of white blood cell crucial for fighting infections, from bone marrow stem cells. It binds to specific G-CSF receptors on myeloid progenitor cells, promoting their proliferation and differentiation into mature neutrophils.

This medication is primarily used to reduce the incidence and duration of neutropenia, a condition characterized by abnormally low levels of neutrophils, which often occurs as a side effect of chemotherapy or in other medical conditions. By increasing neutrophil counts, Filgrastim helps to decrease the risk of serious infections, thereby improving patient outcomes and allowing for the continuation of planned cancer treatments. It is administered via injection, ensuring systemic delivery and rapid action.

Uses

• Treatment of chemotherapy-induced neutropenia.
• Mobilization of peripheral blood progenitor cells.
• Management of severe chronic neutropenia.
• Reduction of infection risk in bone marrow transplant.

Directions For Use

Administer as a subcutaneous injection or intravenous infusion as directed by your healthcare provider. Do not self-administer without proper training.

Benefits

• Significantly reduces the risk of infection.
• Shortens the duration of neutropenia.
• Allows for timely chemotherapy cycles.
• Stimulates neutrophil production effectively.
• Improves patient safety during myelosuppressive therapy.
• Enhances recovery of the immune system.

Side Effects

• Bone pain
• Myalgia (muscle pain)
• Fatigue
• Headache
• Nausea
• Alopecia
• Diarrhea
• Splenomegaly (enlarged spleen)
• Thrombocytopenia
• Injection site reactions
• Acute respiratory distress syndrome (rare)
• Allergic reactions

Safety Measures

• Alcohol - No specific interaction with alcohol is known, but it's generally advisable to limit alcohol intake during medical treatment.
• Pregnancy - Use during pregnancy only if the potential benefits outweigh the potential risks to the fetus. Consult your doctor.
• Breastfeeding - It is unknown if Filgrastim is excreted in human milk. Exercise caution and consult your doctor before breastfeeding.
• Liver - No specific dose adjustment is typically required for liver impairment, but caution is advised in patients with pre-existing liver disease.
• Kidney - No specific dose adjustment is generally required for kidney impairment, but caution is advised in severe renal dysfunction.
• Lung - Use with caution in patients with pre-existing lung conditions, as rare cases of acute respiratory distress syndrome have been reported.

Disclaimer

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