Guficin Alpha 1.6mg Injection

About

Guficin Alpha 1.6mg Injection is a recombinant human granulocyte colony-stimulating factor (G-CSF), a type of cytokine that plays a crucial role in the production, maturation, and activation of neutrophils, a type of white blood cell essential for fighting infections. It works by stimulating the bone marrow to produce more neutrophils, thereby increasing their count in the bloodstream. This action helps to reduce the incidence and duration of neutropenia, a condition characterized by abnormally low neutrophil levels, which often occurs as a side effect of chemotherapy.

By boosting neutrophil counts, Guficin Alpha significantly lowers the risk of serious infections in patients undergoing myelosuppressive chemotherapy. It is also used in other clinical settings, such as for severe chronic neutropenia and for mobilizing hematopoietic stem cells for transplantation. Careful monitoring of blood counts and potential side effects, such as bone pain, is important during treatment.

Uses

• Reduces the incidence of febrile neutropenia in chemotherapy patients.
• Mobilizes hematopoietic stem cells into the peripheral blood for collection.
• Treats severe chronic neutropenia in adults and children.
• Manages neutropenia in patients undergoing bone marrow transplantation.

Directions For Use

Administered via subcutaneous injection by a healthcare professional or trained patient. Dosage and frequency are based on body weight, clinical need, and specific treatment protocol.

Benefits

• Prevents life-threatening infections in neutropenic patients.
• Reduces the duration and severity of chemotherapy-induced neutropenia.
• Allows for on-schedule delivery of chemotherapy cycles.
• Improves patient quality of life by reducing infection risk.
• Supports bone marrow recovery after cytotoxic therapy.
• Well-established efficacy and safety profile in clinical practice.

Side Effects

• Bone pain.
• Muscle pain (myalgia).
• Headache.
• Fatigue.
• Nausea.
• Diarrhea.
• Injection site reactions (pain, redness).
• Splenic rupture (rare but serious).
• Acute respiratory distress syndrome (ARDS, rare).
• Allergic reactions.
• Thrombocytopenia (low platelet count).
• Leukocytosis (high white blood cell count).

Safety Measures

• Alcohol - Generally safe, but excessive alcohol can suppress the immune system, which may counteract the benefits of G-CSF.
• Pregnancy - Use only if clearly needed; animal studies show adverse effects, and human data is limited. Discuss risks and benefits with a doctor.
• Breastfeeding - Unknown if excreted in human milk; caution should be exercised when administered to a nursing mother.
• Liver - No specific dose adjustment required for liver impairment, but use with caution and monitor for adverse effects.
• Kidney - No specific dose adjustment required for renal impairment, but use with caution and monitor for adverse effects.
• Lung - Monitor for signs of acute respiratory distress syndrome (ARDS) or interstitial lung disease; use with caution in patients with pre-existing lung conditions.

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