INOGLA M 1000 10'S

About

INOGLA M 1000 is a combination oral antidiabetic medication, typically comprising a dipeptidyl peptidase-4 (DPP-4) inhibitor (a "gliptin" like Linagliptin or Sitagliptin) and Metformin hydrochloride 1000mg. This combination therapy targets multiple pathways involved in glucose regulation. Metformin, a biguanide, primarily reduces hepatic glucose production and improves insulin sensitivity in peripheral tissues. The DPP-4 inhibitor works by preventing the breakdown of incretin hormones (GLP-1 and GIP), thereby increasing their levels. Elevated incretin levels stimulate glucose-dependent insulin secretion from pancreatic beta cells and suppress glucagon secretion from alpha cells, leading to improved glycemic control without a high risk of hypoglycemia. This dual action provides comprehensive blood sugar management for patients with type 2 diabetes who are not adequately controlled on monotherapy.

Uses

• Management of type 2 diabetes mellitus.
• To improve glycemic control in adults.
• When diet and exercise alone are insufficient.
• As an alternative to separate gliptin and metformin tablets.

Directions For Use

Take one tablet orally once or twice daily with meals, as prescribed by your doctor.

Benefits

• Provides comprehensive blood sugar control.
• Lowers both fasting and postprandial glucose levels.
• Reduces the risk of hypoglycemia compared to sulfonylureas.
• Contributes to modest weight loss or weight neutrality.
• Improves insulin sensitivity and pancreatic function.
• Convenient once or twice daily dosing.

Side Effects

• Nausea
• Diarrhea
• Abdominal pain
• Vomiting
• Headache
• Upper respiratory tract infection
• Nasopharyngitis
• Hypoglycemia (especially with other agents)
• Lactic acidosis (rare, but serious with metformin)
• Joint pain
• Pancreatitis (rare with gliptins)
• Skin reactions

Safety Measures

• Alcohol - Avoid excessive alcohol consumption due to increased risk of lactic acidosis with metformin.
• Pregnancy - Not recommended during pregnancy; consult a doctor for alternative management.
• Breastfeeding - Not recommended during breastfeeding; consult a doctor for advice.
• Liver - Use with caution in patients with liver impairment; metformin is contraindicated in severe cases.
• Kidney - Contraindicated in severe renal impairment due to metformin accumulation and risk of lactic acidosis.
• Lung - Generally safe, but caution with conditions causing hypoxia, which can increase lactic acidosis risk.

Disclaimer

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