GLUCORYL M4 FORTE 15

About

GLUCORYL M4 FORTE is a combination oral antidiabetic medication containing Glimepiride (a sulfonylurea) and Metformin (a biguanide), formulated for the effective management of type 2 diabetes mellitus. Glimepiride works by stimulating the pancreatic beta cells to release insulin, thereby lowering blood glucose levels. Metformin acts by reducing glucose production in the liver, decreasing glucose absorption from the gastrointestinal tract, and enhancing insulin sensitivity in peripheral tissues. This dual-action therapy provides complementary mechanisms to achieve comprehensive glycemic control in patients with type 2 diabetes mellitus, particularly when monotherapy with either agent is insufficient. The "Forte" designation indicates a higher dose of Glimepiride, suitable for patients requiring more intensive glycemic management to achieve their target blood glucose levels and prevent diabetes-related complications.

Uses

• Management of type 2 diabetes mellitus.
• Improvement of glycemic control.
• When diet and exercise alone are not enough.
• As an add-on therapy to other antidiabetic agents.

Directions For Use

Take orally with meals, usually once or twice daily, as directed by your physician. Swallow the tablet whole with water.

Benefits

• Effective blood sugar control.
• Dual mechanism of action.
• Reduces both fasting and post-meal glucose.
• Improved insulin sensitivity.
• May lead to modest weight loss (Metformin effect).
• Convenient fixed-dose combination.

Side Effects

• Hypoglycemia (especially with Glimepiride)
• Nausea
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Fatigue
• Lactic acidosis (rare, Metformin)
• Vitamin B12 deficiency (long-term Metformin)
• Allergic skin reactions
• Weight gain (Glimepiride)
• Transient visual disturbances

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis (Metformin) and hypoglycemia (Glimepiride).
• Pregnancy - Generally not recommended during pregnancy. Consult your doctor to discuss risks and alternative treatments.
• Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk. Seek medical advice.
• Liver - Contraindicated in severe hepatic impairment due to increased risk of lactic acidosis (Metformin) and potential for Glimepiride accumulation.
• Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²) due to Metformin accumulation and increased risk of lactic acidosis.
• Lung - Use with caution in conditions causing hypoxia, suchs as severe respiratory failure, as it may increase the risk of lactic acidosis.

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