Lorbriqua 100mg Tablet 15's

About

Lorbriqua 100mg Tablet is a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor, representing a crucial targeted therapy used in the treatment of specific types of non-small cell lung cancer (NSCLC). It works by precisely blocking the activity of the ALK and ROS1 tyrosine kinases, which are often aberrantly activated or rearranged in certain cancer cells, thereby driving their uncontrolled growth, proliferation, and survival. By effectively inhibiting these key oncogenic signaling pathways, Lorbriqua suppresses tumor proliferation, reduces tumor size, and induces apoptosis in ALK-positive and ROS1-positive malignancies. This precision medicine approach offers a significant therapeutic advantage for patients with these specific genetic alterations, particularly those who have progressed on prior ALK inhibitors, providing a valuable option for advanced disease management and improving patient outcomes.

Uses

• Treatment of ALK-positive metastatic NSCLC.
• Management of ROS1-positive metastatic NSCLC.
• For patients who have progressed on other ALK inhibitors.
• As a targeted therapy for specific genetic mutations.

Directions For Use

Take orally once daily, with or without food, as prescribed by your oncologist.

Benefits

• Highly targeted therapy for specific mutations.
• Effective in patients resistant to other ALK inhibitors.
• Improves progression-free survival.
• Oral administration for patient convenience.
• Can cross the blood-brain barrier, treating brain metastases.
• Offers a significant treatment option for advanced NSCLC.

Side Effects

• Edema (swelling)
• Hypercholesterolemia (high cholesterol)
• Hypertriglyceridemia (high triglycerides)
• Fatigue
• Myalgia (muscle pain)
• Arthralgia (joint pain)
• Cognitive effects (e.g., memory impairment)
• Peripheral neuropathy
• Hypertension (high blood pressure)
• Elevated liver enzymes
• Diarrhea
• Nausea

Safety Measures

• Alcohol - Avoid alcohol as it may increase the risk of liver toxicity and other adverse effects.
• Pregnancy - Contraindicated; can cause fetal harm. Use effective contraception during and after treatment.
• Breastfeeding - Contraindicated; it is unknown if the drug is excreted in human milk and could harm the infant.
• Liver - Use with caution; dose adjustment may be necessary in patients with hepatic impairment.
• Kidney - Use with caution; dose adjustment may be necessary in patients with renal impairment.
• Lung - Monitor for signs of interstitial lung disease (ILD) or pneumonitis; discontinue if suspected.

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