Lupifil P 6mg Injection

About

Lupifil P 6mg Injection contains pegfilgrastim, a pegylated form of recombinant human granulocyte colony-stimulating factor (G-CSF). It works by stimulating the production, maturation, and activation of neutrophils from the bone marrow. Neutrophils are a type of white blood cell crucial for fighting infections. Pegfilgrastim has a prolonged duration of action compared to non-pegylated G-CSF due to its reduced renal clearance, allowing for a single dose per chemotherapy cycle.

The primary clinical application of Lupifil P is to reduce the incidence of febrile neutropenia, a serious complication characterized by fever and a dangerously low neutrophil count, in cancer patients receiving myelosuppressive chemotherapy. By accelerating neutrophil recovery, it helps to minimize the risk of severe infections, allowing patients to maintain their chemotherapy schedules and improve overall treatment outcomes. Its sustained effect provides convenience and reduces the burden of daily injections.

Uses

• Prevention of febrile neutropenia in cancer patients
• Reduction of infection risk during chemotherapy
• Support for patients undergoing myelosuppressive chemotherapy
• Mobilization of hematopoietic stem cells for transplantation

Directions For Use

Administer as a single subcutaneous injection once per chemotherapy cycle, at least 24 hours after chemotherapy. Do not administer within 14 days before the next chemotherapy dose.

Benefits

• Significantly reduces the risk of febrile neutropenia
• Decreases the incidence of infection-related hospitalizations
• Allows for on-schedule chemotherapy administration
• Improves patient quality of life during cancer treatment
• Supports the body's immune system
• Convenient single dose per chemotherapy cycle

Side Effects

• Bone pain
• Muscle pain
• Nausea
• Fatigue
• Headache
• Injection site reactions (pain, redness)
• Splenic rupture (rare but serious)
• Acute respiratory distress syndrome (rare)
• Allergic reactions
• Thrombocytopenia
• Leukocytosis
• Alopecia

Safety Measures

• Alcohol - No direct interaction with alcohol. Generally safe to consume alcohol in moderation, but consult your doctor.
• Pregnancy - Use only if clearly needed and the potential benefits outweigh the risks. Consult your doctor before use during pregnancy.
• Breastfeeding - Use with caution during breastfeeding as it is unknown if the drug is excreted in human milk. Discuss with your physician.
• Liver - No specific dose adjustment is typically needed for patients with liver impairment. Generally considered safe.
• Kidney - No specific dose adjustment is typically needed for patients with kidney conditions. Generally considered safe.
• Lung - Monitor for pulmonary adverse reactions such as cough, fever, and dyspnea. Use with caution in patients with pre-existing lung conditions.

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