Maball 500mg Injection

About

Maball 500mg Injection contains a monoclonal antibody, likely targeting the CD20 antigen found on the surface of B-lymphocytes. By binding to CD20, this medication initiates a cascade of immune responses that lead to the depletion of B-cells. This mechanism is highly effective in treating certain types of cancer, particularly non-Hodgkin's lymphoma and chronic lymphocytic leukemia, where malignant B-cells proliferate uncontrollably. Furthermore, its B-cell depleting action makes it valuable in managing autoimmune diseases like rheumatoid arthritis, where B-cells contribute to inflammation and tissue damage.

Administered intravenously, the treatment typically involves multiple cycles. Patients are closely monitored for infusion-related reactions, which are common, especially during the first infusion. Due to its immunosuppressive effects, there is an increased risk of infections, and patients are often screened for viral infections like Hepatitis B before and during treatment. The goal is to reduce disease activity and improve patient outcomes by selectively targeting and eliminating pathogenic B-cells.

Uses

• Treatment of non-Hodgkin's lymphoma.
• Management of chronic lymphocytic leukemia.
• Treatment of severe, active rheumatoid arthritis.
• Management of certain vasculitides (e.g., GPA, MPA).

Directions For Use

This injection is administered intravenously by a healthcare professional. Pre-medication may be given to reduce infusion reactions.

Benefits

• Effective in treating various B-cell malignancies.
• Induces remission in severe autoimmune diseases.
• Reduces disease activity and progression.
• Can be used in combination with chemotherapy.
• Well-established safety and efficacy profile.
• Improves long-term outcomes for many patients.

Side Effects

• Infusion-related reactions (fever, chills, nausea)
• Fatigue
• Headache
• Nausea
• Diarrhea
• Increased risk of infection
• Myelosuppression (low blood counts)
• Progressive multifocal leukoencephalopathy (PML) (rare)
• Hepatitis B reactivation
• Skin rash
• Hypotension
• Cardiac arrhythmias

Safety Measures

• Alcohol - No specific contraindication, but avoid if it exacerbates underlying conditions or side effects.
• Pregnancy - Not recommended; can cause B-cell depletion in the fetus. Use effective contraception during and for 12 months after treatment.
• Breastfeeding - Not recommended; antibodies can pass into breast milk. Discontinue breastfeeding during and for 6 months after treatment.
• Liver - Use with caution in patients with active or chronic Hepatitis B infection; screen and monitor closely for reactivation.
• Kidney - No specific dose adjustment required for renal impairment, but caution is advised in severe cases.
• Lung - May cause pulmonary toxicity (e.g., interstitial lung disease); monitor for new or worsening respiratory symptoms.

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