Mestrolyst 80mg Tablet

About

Megestrol acetate is a synthetic progestin with established antineoplastic and appetite-stimulating properties, making it a versatile agent in oncology and palliative care. It is primarily employed in the palliative treatment of advanced hormone-sensitive cancers, specifically breast and endometrial carcinomas. In these contexts, its antineoplastic mechanism is thought to involve anti-estrogenic effects, potentially by downregulating estrogen receptors or altering the metabolism of endogenous hormones, thereby inhibiting tumor growth. Additionally, megestrol acetate is widely used for the management of anorexia, cachexia, or unexplained significant weight loss, particularly in patients with AIDS or advanced cancer. In these conditions, it is believed to stimulate appetite through central mechanisms, possibly involving the modulation of neuropeptide Y, leading to improved nutritional status and enhanced quality of life. It is administered orally and generally well-absorbed.

Uses

• Palliative treatment of advanced breast cancer.
• Palliative treatment of advanced endometrial cancer.
• Management of anorexia and cachexia in AIDS patients.
• Treatment of unexplained significant weight loss.

Directions For Use

Taken orally, usually once daily, with or without food, depending on the specific indication and dosage.

Benefits

• Effective in hormone-sensitive cancers.
• Improves appetite and promotes weight gain.
• Enhances quality of life in cachectic patients.
• Reduces tumor growth in some cancers.
• Convenient oral administration.
• Well-tolerated in many patients.

Side Effects

• Weight gain
• Thromboembolic events
• Nausea
• Vomiting
• Diarrhea
• Breakthrough bleeding
• Hot flashes
• Adrenal suppression
• Hyperglycemia
• Edema
• Headache
• Rash

Safety Measures

• Alcohol - No specific interaction, but general moderation is advised.
• Pregnancy - Contraindicated in pregnancy due to potential for fetal harm; use effective contraception.
• Breastfeeding - Discontinue breastfeeding as megestrol acetate may be excreted in breast milk and affect the infant.
• Liver - Use with caution in patients with hepatic impairment; monitor liver function.
• Kidney - Use with caution in patients with renal impairment; monitor for adverse effects.
• Lung - Generally safe for lung conditions, but monitor for any unusual respiratory symptoms.

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