Metrixafor 24mg Injection

About

Metrixafor 24mg Injection is a specialized hematopoietic stem cell mobilizer, functioning as a selective antagonist of the CXCR4 chemokine receptor. Its therapeutic action is centered on disrupting the normal interaction between stromal cell-derived factor-1 alpha (SDF-1α) and the CXCR4 receptor, which is crucial for anchoring hematopoietic stem cells within the bone marrow microenvironment. By blocking this binding, Metrixafor effectively dislodges these vital stem cells from the bone marrow, facilitating their rapid release and migration into the peripheral bloodstream. This mobilization process is critical for subsequent collection via apheresis, preparing patients for autologous stem cell transplantation. It is primarily used in conjunction with granulocyte-colony stimulating factor (G-CSF) to significantly enhance the yield of stem cells, particularly in patients with certain types of lymphomas and multiple myeloma who require transplantation, thereby improving the success rates of these life-saving procedures and ensuring adequate cell counts for engraftment.

Uses

• Mobilization of hematopoietic stem cells for autologous transplantation.
• Used in patients with non-Hodgkin's lymphoma.
• Used in patients with multiple myeloma.
• Enhances stem cell collection when G-CSF alone is insufficient.

Directions For Use

This medication is administered by a healthcare professional as a subcutaneous injection. It is typically given daily for a few days prior to apheresis, in conjunction with G-CSF.

Benefits

• Increases the yield of hematopoietic stem cells.
• Facilitates successful autologous stem cell transplantation.
• Reduces the number of apheresis sessions required.
• Offers an option for patients who are poor mobilizers with G-CSF alone.
• Improves the likelihood of engraftment post-transplant.
• Supports advanced cancer treatment protocols.

Side Effects

• Injection site reactions (pain, redness)
• Diarrhea
• Nausea
• Fatigue
• Headache
• Dizziness
• Abdominal pain
• Arthralgia (joint pain)
• Paresthesia (tingling)
• Leukocytosis (increased white blood cells)
• Thrombocytopenia (decreased platelets)
• Splenomegaly (enlarged spleen)

Safety Measures

• Alcohol - No specific contraindication, but general health advice applies.
• Pregnancy - Not recommended during pregnancy due to potential fetal harm. Effective contraception is advised for women of childbearing potential.
• Breastfeeding - Discontinue breastfeeding during treatment due to unknown excretion into breast milk and potential harm to the infant.
• Liver - Use with caution in patients with severe liver impairment; dose adjustment may be considered.
• Kidney - Dose adjustment is required for patients with moderate to severe renal impairment.
• Lung - Generally safe, but monitor for any unusual respiratory symptoms, especially in patients with pre-existing conditions.

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