Mytera 500mg Tablet

About

Mycophenolate mofetil is a powerful immunosuppressant agent that selectively inhibits inosine monophosphate dehydrogenase (IMPDH), a key enzyme crucial for the de novo synthesis of guanosine nucleotides. This selective inhibition primarily impacts lymphocytes, including T and B cells, which are highly dependent on this specific pathway for their proliferation and function, unlike other cell types that can utilize alternative salvage pathways. By effectively depleting intracellular guanosine nucleotides, mycophenolate significantly suppresses lymphocyte proliferation, differentiation, and antibody formation, thereby mitigating unwanted immune responses. It is widely utilized in transplant medicine to prevent acute and chronic organ rejection following solid organ transplantation and is also effective in the treatment of various severe autoimmune diseases.

Uses

• Prevention of organ rejection in transplant patients.
• Treatment of certain autoimmune diseases.
• Management of lupus nephritis.
• Used in combination with other immunosuppressants.

Directions For Use

Take orally as directed by your physician, usually twice daily. Swallow tablets whole with water, do not crush or chew.

Benefits

• Effective immunosuppressant.
• Reduces risk of organ rejection.
• Manages autoimmune disease activity.
• Available in oral formulation.
• Can be used long-term.
• Well-established safety profile in its indications.

Side Effects

• Diarrhea
• Nausea and vomiting
• Abdominal pain
• Leukopenia (low white blood cell count)
• Anemia
• Thrombocytopenia
• Increased risk of infection
• Headache
• Hypertension
• Tremor
• Insomnia
• Rash

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it may increase the risk of gastrointestinal side effects or liver toxicity.
• Pregnancy - Contraindicated in pregnancy due to significant teratogenic risk (birth defects). Effective contraception is mandatory before, during, and after treatment.
• Breastfeeding - Not recommended during breastfeeding as the drug may pass into breast milk and cause serious adverse effects in the infant.
• Liver - Use with caution in patients with severe hepatic impairment; dose adjustments may be necessary.
• Kidney - Use with caution in patients with severe chronic renal impairment; dose adjustments may be required.
• Lung - Rare cases of interstitial lung disease or pulmonary fibrosis have been reported; monitor for new or worsening respiratory symptoms.

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