NEBICARD 5

About

Nebicard 5, containing Nebivolol 5mg, is a highly selective beta-1 adrenergic receptor blocker with additional vasodilatory properties mediated by nitric oxide release. It is primarily used in the management of essential hypertension and chronic stable heart failure. Unlike some other beta-blockers, nebivolol's unique mechanism of action contributes to its favorable hemodynamic profile, often resulting in less impact on heart rate and peripheral vascular resistance. By reducing heart rate, myocardial contractility, and peripheral vascular resistance, it effectively lowers blood pressure and reduces the workload on the heart. In heart failure, it helps to improve cardiac function and reduce mortality and morbidity. Its high selectivity for beta-1 receptors generally leads to a lower incidence of respiratory side effects compared to non-selective beta-blockers, making it a suitable option for many patients.

Uses

• Treatment of essential hypertension.
• Management of chronic stable heart failure.
• Reduction of cardiovascular risk.
• Improvement of cardiac function.

Directions For Use

Take one tablet orally once daily, preferably at the same time each day, with or without food. Do not stop taking this medication abruptly without consulting your doctor.

Benefits

• Effectively lowers blood pressure.
• Improves symptoms of heart failure.
• High beta-1 selectivity.
• Vasodilatory properties.
• Generally well-tolerated.
• Convenient once-daily dosing.

Side Effects

• Headache
• Dizziness
• Fatigue
• Nausea
• Diarrhea
• Bradycardia (slow heart rate)
• Cold extremities
• Paresthesia
• Shortness of breath
• Edema
• Insomnia
• Depression

Safety Measures

• Alcohol - Alcohol can potentiate the blood pressure-lowering effect of nebivolol, leading to increased dizziness or lightheadedness. Use alcohol cautiously.
• Pregnancy - Nebivolol is generally not recommended during pregnancy, especially in the second and third trimesters, due to potential fetal harm. Consult your doctor.
• Breastfeeding - Nebivolol is excreted in breast milk. Breastfeeding is not recommended during treatment due to potential adverse effects on the infant.
• Liver - Use with caution in patients with mild to moderate hepatic impairment. Dose adjustment may be necessary. Contraindicated in severe hepatic impairment.
• Kidney - Dose adjustment is required for patients with moderate to severe renal impairment (creatinine clearance < 30 mL/min).
• Lung - While highly selective, use with caution in patients with severe obstructive airway disease (e.g., asthma, COPD) as beta-blockers can exacerbate bronchospasm.

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