Nindalieva 150mg Capsule

About

Nindalieva 150mg Capsule is a multi-targeted tyrosine kinase inhibitor (TKI) that selectively blocks several growth factor receptors and kinases involved in angiogenesis, fibrosis, and tumor growth. Its primary targets include vascular endothelial growth factor receptors (VEGFR 1-3), fibroblast growth factor receptors (FGFR 1-3), and platelet-derived growth factor receptors (PDGFR α/β), as well as Fms-like tyrosine kinase 3 (FLT3) and RET. By inhibiting these pathways, Nindalieva helps to reduce the formation of new blood vessels that feed tumors, suppress the proliferation of cancer cells, and mitigate fibrotic processes, which are often associated with certain chronic diseases.

This broad inhibitory profile makes Nindalieva 150mg Capsule effective in treating specific types of cancer and fibrotic conditions. It is particularly noted for its role in managing idiopathic pulmonary fibrosis (IPF) and certain advanced non-small cell lung cancers (NSCLC). The drug's ability to target multiple pathways contributes to its therapeutic efficacy, but also necessitates careful monitoring for a range of potential side effects, especially gastrointestinal and liver-related toxicities, to ensure patient safety and optimize the therapeutic regimen.

Uses

• Treatment of idiopathic pulmonary fibrosis (IPF).
• Management of advanced non-small cell lung cancer (NSCLC) of adenocarcinoma histology.
• Treatment of systemic sclerosis-associated interstitial lung disease (SSc-ILD).
• Therapy for chronic fibrosing interstitial lung diseases with a progressive phenotype.

Directions For Use

Take Nindalieva 150mg Capsule orally twice daily, approximately 12 hours apart, with food, as directed by your physician. Swallow the capsule whole; do not chew or crush it.

Benefits

• Inhibits multiple growth factor receptors.
• Reduces angiogenesis and fibrosis.
• Slows disease progression in IPF and SSc-ILD.
• Effective in specific types of NSCLC.
• May improve lung function.
• Offers a targeted therapeutic option.

Side Effects

• Diarrhea
• Nausea
• Vomiting
• Abdominal pain
• Decreased appetite
• Weight loss
• Liver enzyme elevation
• Fatigue
• Headache
• Hypertension
• Rash
• Proteinuria

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may increase the risk of liver enzyme elevation and other gastrointestinal side effects.
• Pregnancy - Nindalieva 150mg Capsule is contraindicated during pregnancy due to potential embryofetal toxicity. Women of childbearing potential must use effective contraception.
• Breastfeeding - Breastfeeding is not recommended during treatment with Nindalieva 150mg Capsule and for at least 3 days after the last dose, as the drug may be excreted in breast milk.
• Liver - Use with extreme caution in patients with hepatic impairment; dose adjustments are necessary, and liver function should be monitored closely and regularly.
• Kidney - No dose adjustment is typically required for mild to moderate renal impairment, but caution is advised in severe cases.
• Lung - Monitor for new or worsening respiratory symptoms, especially in patients with pre-existing lung conditions, though it is used for lung fibrosis.

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