OLKEM AM 40 TAB

About This medication is a fixed-dose combination therapy indicated for the management of essential hypertension, particularly in patients whose blood pressure is not adequately controlled with monotherapy. It combines Olmesartan 40mg, an angiotensin II receptor blocker (ARB), with Amlodipine, a dihydropyridine calcium channel blocker (CCB). Olmesartan works by selectively blocking the binding of angiotensin II to the AT1 receptor, leading to vasodilation and reduced aldosterone secretion, which helps lower blood pressure. Amlodipine inhibits the influx of calcium ions into vascular smooth muscle and myocardial cells, resulting in peripheral vasodilation and reduced peripheral vascular resistance. The synergistic action of these two agents provides enhanced and sustained blood pressure control through complementary mechanisms, making it an effective option for achieving target blood pressure and reducing cardiovascular risk, especially in patients who may also benefit from the anti-anginal effects of amlodipine. Uses Treatment of essential hypertension. When monotherapy is insufficient. Reduction of cardiovascular risk in hypertensive patients. Management of hypertension with co-existing angina. Directions For Use Take orally once daily, preferably at the same time each day, with or without food, as directed by your physician. Benefits Effective and sustained blood pressure reduction. Dual mechanism of action. Improved patient adherence. Provides anti-anginal benefits. Reduces risk of cardiovascular events. Suitable for moderate to severe hypertension. Side Effects Dizziness Headache Fatigue Nausea Peripheral edema Hypotension Flushing Palpitations Abdominal pain Somnolence Rash Muscle cramps Safety Measures Alcohol - Avoid or limit alcohol consumption as it can further lower blood pressure and increase the risk of dizziness. Pregnancy - Contraindicated during pregnancy, especially in the second and third trimesters, due to potential fetal harm. Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk and affect the infant. Liver - Use with caution in patients with hepatic impairment; dosage adjustments may be necessary. Kidney - Use with caution in patients with renal impairment; monitor kidney function closely. Lung - Generally safe for use in patients with lung conditions, but monitor for any unusual respiratory symptoms. Disclaimer MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment. Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub. Our goal is to complement, not replace, the essential doctor-patient relationship.