Oplatin 50mg Injection

About

Oplatin Injection, containing oxaliplatin, is a platinum-based antineoplastic agent primarily used in the treatment of various cancers, particularly colorectal cancer. It functions by forming DNA adducts and interstrand cross-links, which inhibit DNA replication and transcription, ultimately leading to apoptosis of cancer cells. This cytotoxic action is cell-cycle non-specific, making it effective against a broad range of proliferating cells. It is often administered intravenously as part of combination chemotherapy regimens, such as FOLFOX, to enhance its efficacy and overcome potential drug resistance. Its unique mechanism of action distinguishes it from other platinum compounds like cisplatin and carboplatin, offering a different toxicity profile and therapeutic spectrum.

Oplatin is crucial in both adjuvant settings, following surgical resection of primary tumors, and in metastatic disease to control tumor growth and improve patient outcomes. Its clinical utility extends to other gastrointestinal malignancies, where it contributes significantly to disease management. Careful monitoring for adverse effects, especially peripheral neuropathy, is essential during treatment.

Uses

• Treatment of metastatic colorectal cancer.
• Adjuvant treatment of stage III colon cancer.
• Management of gastric cancer.
• Therapy for pancreatic cancer.

Directions For Use

Oplatin Injection is administered intravenously by a qualified healthcare professional. The dosage and duration of treatment are determined by the patient's specific cancer type, stage, body surface area, and overall health.

Benefits

• Highly effective against colorectal cancer.
• Often used in synergistic combination regimens.
• Improves progression-free and overall survival.
• Well-established efficacy in various solid tumors.
• Offers a distinct mechanism from other platinum agents.
• Can be used in both adjuvant and metastatic settings.

Side Effects

• Peripheral neuropathy (acute and chronic)
• Nausea and vomiting
• Fatigue and asthenia
• Myelosuppression (anemia, leukopenia, thrombocytopenia)
• Diarrhea
• Stomatitis/mucositis
• Allergic reactions (rash, pruritus, bronchospasm)
• Hepatotoxicity (elevated liver enzymes)
• Nephrotoxicity (renal impairment)
• Ototoxicity (hearing loss, tinnitus)
• Alopecia (hair thinning)
• Electrolyte disturbances (hypokalemia, hypocalcemia)

Safety Measures

• Alcohol - Avoid or limit alcohol consumption due to potential for increased liver toxicity and gastrointestinal irritation, which can exacerbate drug side effects.
• Pregnancy - Oplatin is contraindicated during pregnancy as it can cause severe fetal harm. Women of childbearing potential must use effective contraception during and for several months after treatment.
• Breastfeeding - Breastfeeding is not recommended during Oplatin treatment and for a period thereafter, as the drug may pass into breast milk and pose a risk to the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustments may be necessary, and liver function should be closely monitored throughout therapy.
• Kidney - Administer with caution in patients with kidney dysfunction; dose modifications are typically required based on creatinine clearance to prevent accumulation and toxicity.
• Lung - Rare but serious pulmonary toxicity, including interstitial lung disease, can occur. Monitor patients for new or worsening respiratory symptoms like cough or dyspnea.

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