Oxalimax 50mg Injection

About

Oxaliplatin is a platinum-based antineoplastic agent primarily utilized in the treatment of advanced and adjuvant colorectal cancer. Its mechanism of action involves the formation of platinum-DNA adducts, which leads to the inhibition of DNA replication and transcription. This disruption of cellular processes results in cell cycle arrest and ultimately induces apoptosis in rapidly proliferating cancer cells. Oxaliplatin's cytotoxic effects are crucial for its anticancer activity, making it an essential component of various chemotherapy regimens, often administered in combination with fluoropyrimidines like 5-fluorouracil and leucovorin. It is effective against a broad spectrum of solid tumors, aiming to slow disease progression and improve patient outcomes by targeting the DNA of rapidly dividing cancer cells. The drug is typically administered intravenously under strict medical supervision due to its potent nature and potential for significant side effects.

Uses

• Adjuvant treatment of stage III colon cancer.
• Treatment of advanced colorectal cancer.
• Treatment of gastric cancer (off-label).
• Treatment of pancreatic cancer (off-label).

Directions For Use

Administered intravenously by a healthcare professional. Dosage and infusion rate are determined by the patient's body surface area and treatment regimen.

Benefits

• Effective against various stages of colorectal cancer.
• Can improve disease-free survival in adjuvant settings.
• Often used in combination regimens for enhanced efficacy.
• Demonstrates activity in metastatic disease.
• Part of standard first-line and second-line treatments.
• Can help shrink tumors and slow disease progression.

Side Effects

• Peripheral neuropathy (cold-induced, persistent)
• Nausea and vomiting
• Diarrhea
• Fatigue
• Myelosuppression (anemia, leukopenia, thrombocytopenia)
• Stomatitis/mucositis
• Hepatotoxicity
• Allergic reactions (rash, dyspnea, hypotension)
• Nephrotoxicity
• Ototoxicity
• Pulmonary fibrosis (rare)

Safety Measures

• Alcohol - Avoid alcohol during treatment as it may exacerbate gastrointestinal side effects and potentially interact with the drug's metabolism, increasing toxicity.
• Pregnancy - Oxaliplatin is contraindicated in pregnancy due to its genotoxic and teratogenic potential. Effective contraception is required for both male and female patients during and after treatment.
• Breastfeeding - Breastfeeding is contraindicated during oxaliplatin treatment and for a period after, as the drug may be excreted in breast milk and cause serious adverse effects in the infant.
• Liver - Use with caution in patients with pre-existing liver impairment. Dose adjustments may be necessary, and liver function should be closely monitored due to potential hepatotoxicity.
• Kidney - Use with caution in patients with renal impairment. Dose adjustments are typically required based on creatinine clearance, and renal function should be regularly assessed.
• Lung - Use with caution in patients with pre-existing lung conditions. Although rare, pulmonary toxicity can occur, and patients should be monitored for respiratory symptoms.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.