Pangraf 1mg Capsule

About

Pangraf Capsule, containing Tacrolimus, is a potent immunosuppressant medication primarily used to prevent organ rejection in patients who have received a kidney, liver, or heart transplant. It works by inhibiting the activity of calcineurin, a protein involved in the activation of T-lymphocytes, which are crucial components of the immune system responsible for recognizing and attacking foreign tissues. By suppressing the immune response, Tacrolimus helps the body accept the transplanted organ, significantly reducing the risk of rejection episodes and improving long-term graft survival.

This medication requires careful and continuous monitoring of blood levels to ensure therapeutic efficacy while minimizing the risk of severe side effects. It is a cornerstone of post-transplant immunosuppressive therapy, often used in combination with other immunosuppressants to achieve optimal outcomes and maintain the health of the transplanted organ.

Uses

• Prevention of kidney transplant rejection.
• Prevention of liver transplant rejection.
• Prevention of heart transplant rejection.
• Treatment of organ rejection (in some cases).

Directions For Use

Take orally, usually twice daily, exactly as prescribed by your doctor. Do not crush or chew the capsule.

Benefits

• Significantly reduces organ rejection risk.
• Improves long-term transplant success rates.
• Allows the body to accept the new organ.
• Essential for post-transplant care.
• Available in various strengths for precise dosing.
• Helps maintain organ function.

Side Effects

• Kidney dysfunction (nephrotoxicity)
• High blood pressure (hypertension)
• Diabetes mellitus (new-onset)
• Tremors
• Headache
• Nausea and vomiting
• Diarrhea
• Insomnia
• Increased risk of infections
• Increased risk of certain cancers (lymphoma)
• Hair loss
• Electrolyte imbalances (e.g., hyperkalemia)

Safety Measures

• Alcohol - Avoid alcohol as it can increase the risk of side effects, particularly liver toxicity, and interact with the medication.
• Pregnancy - Tacrolimus can be harmful to the fetus; use only if the potential benefit justifies the potential risk, under strict medical supervision.
• Breastfeeding - Tacrolimus passes into breast milk and can harm the infant; breastfeeding is generally not recommended while on this medication.
• Liver - Use with caution in patients with liver impairment; dosage adjustments may be necessary, and liver function should be closely monitored.
• Kidney - Tacrolimus is nephrotoxic; kidney function must be closely monitored, and dosage adjusted to prevent or manage kidney damage.
• Lung - Use with caution in patients with pre-existing lung conditions, as tacrolimus can rarely cause interstitial lung disease.

Disclaimer

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