Temodal 100mg Capsule

About

Temodal 100mg Capsule contains temozolomide, an oral alkylating agent widely employed in the treatment of specific brain cancers, including glioblastoma multiforme and anaplastic astrocytoma. This prodrug is converted in the body to its active metabolite, MTIC, which then methylates DNA, primarily at the O6 position of guanine. This methylation leads to DNA damage, which is recognized by the cell's repair machinery. If the damage is extensive or improperly repaired, it triggers cell cycle arrest and programmed cell death (apoptosis) in rapidly dividing cancer cells. The ability of temozolomide to readily cross the blood-brain barrier is a crucial factor in its effectiveness against central nervous system malignancies, making it an indispensable component of chemotherapy regimens for these challenging cancers. Its oral formulation also offers significant convenience for patients.

Uses

• Newly diagnosed glioblastoma multiforme
• Refractory anaplastic astrocytoma
• Other malignant gliomas
• Certain neuroendocrine tumors (off-label)

Directions For Use

Take orally on an empty stomach, preferably at bedtime, to minimize nausea. Swallow capsules whole with water.

Benefits

• Prolongs survival in glioblastoma patients
• Effective against brain tumors
• Oral administration for convenience
• Can be used with radiation therapy
• Reduces tumor growth
• Improves progression-free survival

Side Effects

• Nausea
• Vomiting
• Fatigue
• Headache
• Constipation
• Myelosuppression (low blood counts)
• Hair loss (alopecia)
• Anorexia
• Rash
• Diarrhea
• Dizziness
• Opportunistic infections

Safety Measures

• Alcohol - It is advisable to limit or avoid alcohol consumption as it may worsen gastrointestinal side effects and fatigue.
• Pregnancy - Temodal is contraindicated in pregnancy due to its teratogenic effects; women must use effective contraception.
• Breastfeeding - Breastfeeding is not recommended during treatment and for a period after due to potential harm to the infant.
• Liver - Use with caution in patients with severe hepatic impairment; regular monitoring of liver function tests is essential.
• Kidney - No specific dose adjustment is typically required for mild to moderate renal impairment, but close monitoring is advised in severe cases.
• Lung - Patients should be monitored for signs of pulmonary toxicity, such as interstitial pneumonitis, though rare.

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