Temosted 100mg Capsule

About

Temozolomide is an oral alkylating agent primarily utilized in the treatment of specific types of brain tumors, including newly diagnosed glioblastoma multiforme and refractory anaplastic astrocytoma. Its mechanism of action involves interfering with the DNA of rapidly dividing cancer cells, leading to their apoptosis and inhibiting further proliferation. This cytotoxic effect is crucial in managing aggressive malignancies where uncontrolled cell growth is a hallmark. The drug's ability to penetrate the blood-brain barrier is a significant advantage, allowing it to reach tumor sites within the central nervous system effectively.

It is often administered in cycles, either alone or in combination with radiation therapy, depending on the specific cancer type and stage. For newly diagnosed glioblastoma, it is typically given concurrently with radiotherapy followed by adjuvant cycles. For anaplastic astrocytoma that has recurred or progressed, it serves as a valuable second-line treatment option. Regular monitoring of blood counts is essential during treatment due to its myelosuppressive effects.

Uses

• Treatment of newly diagnosed glioblastoma multiforme.
• Treatment of refractory anaplastic astrocytoma.
• Management of certain other advanced brain tumors.
• Used in combination with radiation therapy for specific indications.

Directions For Use

Take the capsule whole on an empty stomach, preferably at bedtime or at least one hour before food. Follow your doctor's prescribed dosage and schedule strictly.

Benefits

• Oral administration offers convenience for patients.
• Effective against specific aggressive brain tumors.
• Can cross the blood-brain barrier to target CNS cancers.
• May improve progression-free survival in glioblastoma.
• Used in combination to enhance treatment efficacy.
• Part of standard treatment protocols for certain brain cancers.

Side Effects

• Nausea and vomiting
• Fatigue
• Headache
• Constipation or diarrhea
• Loss of appetite
• Hair loss (alopecia)
• Myelosuppression (low blood counts)
• Thrombocytopenia (low platelets)
• Leukopenia (low white blood cells)
• Anemia
• Infections due to weakened immune system

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate side effects like nausea and fatigue, and could potentially interact with the medication.
• Pregnancy - Temozolomide is contraindicated in pregnancy due to its genotoxic and teratogenic potential. Effective contraception is essential for both male and female patients during and after treatment.
• Breastfeeding - Breastfeeding is not recommended during temozolomide treatment and for a period after, as the drug may be excreted in breast milk and could harm the infant.
• Liver - Use with caution in patients with severe hepatic impairment, as dose adjustments may be necessary. Liver function should be monitored regularly.
• Kidney - Use with caution in patients with severe renal impairment. While not extensively studied, dose adjustments might be considered based on individual patient response and toxicity.
• Lung - Rarely, interstitial pneumonitis or pulmonary fibrosis can occur. Monitor for new or worsening respiratory symptoms, especially in patients with pre-existing lung conditions.

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