Temright 250mg Capsule

About

Temozolomide is an oral alkylating agent that serves as a prodrug, spontaneously converting to its active metabolite, MTIC (5-(3-methyl-1-triazen-1-yl)imidazole-4-carboxamide), at physiological pH. MTIC then methylates DNA at various sites, primarily at the O6 position of guanine, leading to DNA damage and subsequent apoptosis in rapidly dividing cells. This mechanism makes it particularly effective in the treatment of certain brain tumors, including glioblastoma multiforme and anaplastic astrocytoma, due to its ability to cross the blood-brain barrier. It is often used in combination with radiation therapy for newly diagnosed glioblastoma.

Uses

• Treatment of newly diagnosed glioblastoma multiforme.
• Management of refractory anaplastic astrocytoma.
• Used in combination with radiation therapy for glioblastoma.
• Treatment of other high-grade gliomas (off-label).

Directions For Use

Take this capsule orally, usually on an empty stomach, at the same time each day, as directed by your physician.

Benefits

• Effective in treating specific types of brain tumors.
• Crosses the blood-brain barrier efficiently.
• Improves overall survival in glioblastoma patients.
• Can be used in combination with radiation therapy.
• Oral administration offers convenience and flexibility.
• Well-established efficacy in its indications.

Side Effects

• Nausea
• Vomiting
• Fatigue
• Headache
• Constipation
• Myelosuppression (thrombocytopenia, neutropenia)
• Alopecia (hair loss)
• Skin rash
• Anorexia (loss of appetite)
• Dizziness
• Asthenia (weakness)
• Opportunistic infections (e.g., PCP)

Safety Measures

• Alcohol - Avoid or limit alcohol consumption due to potential for increased nausea, vomiting, and central nervous system effects.
• Pregnancy - Not recommended during pregnancy due to potential for fetal harm. Women of childbearing potential should use effective contraception.
• Breastfeeding - Not recommended during breastfeeding as the drug may pass into breast milk and cause serious adverse effects in the infant.
• Liver - Use with caution in patients with liver impairment. Close monitoring of liver function tests is advised, and dose adjustments may be necessary.
• Kidney - Use with caution in patients with kidney impairment. No specific dose adjustment is typically required for mild to moderate impairment.
• Lung - Monitor for pneumocystis pneumonia (PCP) and other opportunistic infections, especially when used with corticosteroids. Prophylaxis may be required.

Disclaimer

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