TOPOTEC 2.5MG INJ VIAL

About

TOPOTEC 2.5MG INJ VIAL contains Topotecan, a semisynthetic derivative of camptothecin and a highly effective antineoplastic agent. Its mechanism of action involves the inhibition of topoisomerase I, an enzyme critical for relieving torsional strain in DNA during replication, transcription, and repair. Topotecan specifically binds to the topoisomerase I-DNA complex, preventing the re-ligation of DNA single-strand breaks. This interference leads to an accumulation of DNA damage, particularly during the S-phase of the cell cycle, as the replication fork collides with the stabilized cleavable complex. The resulting extensive DNA damage ultimately triggers apoptosis in rapidly proliferating cancer cells. Administered intravenously, topotecan is a valuable therapeutic option for several advanced and refractory solid tumors, including ovarian cancer, small cell lung cancer, and cervical cancer, often providing crucial benefits in patients who have failed other treatments.

Uses

• Treatment of ovarian cancer (metastatic).
• Management of small cell lung cancer (relapsed).
• Therapy for cervical cancer (recurrent or metastatic).
• Treatment of other solid tumors in specific protocols.

Directions For Use

Administered intravenously by a qualified healthcare professional. Dosage and schedule are determined by the specific cancer and patient's condition.

Benefits

• Effective against several refractory cancers.
• Offers an option for relapsed or metastatic disease.
• Can be used as a single agent or in combination.
• Well-studied in clinical trials.
• Contributes to disease control and palliation.
• Available in an injectable form for systemic delivery.

Side Effects

• Myelosuppression (neutropenia, thrombocytopenia, anemia)
• Nausea and vomiting
• Diarrhea
• Constipation
• Fatigue and asthenia
• Alopecia (hair loss)
• Abdominal pain
• Stomatitis
• Fever
• Headache
• Anorexia
• Infection

Safety Measures

• Alcohol - Avoid alcohol during treatment as it may exacerbate gastrointestinal side effects or liver toxicity.
• Pregnancy - Contraindicated in pregnancy due to significant risk of fetal harm. Effective contraception is essential.
• Breastfeeding - Not recommended during breastfeeding as the drug is likely excreted in breast milk and can harm the infant.
• Liver - Use with caution in patients with moderate hepatic impairment; dose reduction may be necessary.
• Kidney - Use with caution in patients with moderate to severe renal impairment; dose reduction is often necessary.
• Lung - Monitor for pulmonary toxicity, including interstitial lung disease, especially in patients with pre-existing lung conditions.

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