TSART 40 10S

About

Telmisartan is an angiotensin II receptor blocker (ARB) primarily used for the treatment of hypertension and the reduction of cardiovascular risk. It works by selectively blocking the AT1 receptor, preventing angiotensin II from binding and exerting its vasoconstrictive and aldosterone-stimulating effects. This leads to vasodilation, decreased peripheral vascular resistance, and a reduction in blood pressure. Unlike ACE inhibitors, ARBs do not inhibit the breakdown of bradykinin, which means they are less likely to cause the persistent dry cough often associated with ACE inhibitors.

Telmisartan also exhibits a long duration of action, allowing for once-daily dosing, which can improve patient adherence. Beyond blood pressure control, it has demonstrated benefits in reducing the risk of myocardial infarction, stroke, and cardiovascular death in high-risk patients, making it a valuable therapeutic option in comprehensive cardiovascular management.

Uses

• Treatment of essential hypertension.
• Reduction of cardiovascular morbidity and mortality.
• Prevention of stroke and myocardial infarction.
• Management of diabetic nephropathy.

Directions For Use

Take one tablet orally once daily, with or without food, as directed by your healthcare provider.

Benefits

• Effective in lowering high blood pressure.
• Reduces risk of heart attack and stroke.
• Long-lasting effect for once-daily dosing.
• Lower incidence of cough compared to ACE inhibitors.
• Provides cardiovascular protection.
• Well-tolerated by most patients.

Side Effects

• Dizziness
• Headache
• Fatigue
• Nausea
• Diarrhea
• Hypotension
• Back pain
• Upper respiratory tract infection
• Hyperkalemia (rare)
• Angioedema (very rare)
• Renal dysfunction (rare)
• Muscle cramps

Safety Measures

• Alcohol - Avoid alcohol as it can enhance the blood pressure-lowering effect and increase the risk of dizziness or fainting.
• Pregnancy - Contraindicated during the second and third trimesters of pregnancy due to risk of fetal harm and death.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and affect the infant.
• Liver - Use with caution in patients with liver impairment; monitor liver function tests regularly.
• Kidney - Use with caution and adjust dose in patients with severe kidney impairment; monitor renal function and potassium levels closely.
• Lung - Generally safe for use in patients with lung conditions; less likely to cause cough than ACE inhibitors.

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