VAPTOLVA 1X1

About

Vaptolva is a selective vasopressin V2-receptor antagonist primarily used in the management of hyponatremia. It works by blocking the action of vasopressin (antidiuretic hormone) in the kidneys, leading to increased free water excretion without significant loss of electrolytes like sodium and potassium. This mechanism helps to raise serum sodium concentrations in patients with clinically significant euvolemic and hypervolemic hyponatremia, including those associated with heart failure, cirrhosis, and Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Careful monitoring of serum sodium levels is crucial during treatment initiation and dose adjustments to prevent rapid correction of hyponatremia, which can lead to serious neurological complications.

Uses

• Treatment of euvolemic hyponatremia.
• Management of hypervolemic hyponatremia.
• Associated with heart failure.
• Associated with Syndrome of Inappropriate Antidiuretic Hormone (SIADH).

Directions For Use

Administer orally once daily, typically starting with a low dose. Dosage adjustments should be made based on serum sodium levels and clinical response.

Benefits

• Increases serum sodium levels.
• Promotes free water excretion.
• Reduces fluid overload in certain conditions.
• Improves symptoms associated with hyponatremia.
• Specific action on V2 vasopressin receptors.
• Oral administration for convenience.

Side Effects

• Thirst.
• Dry mouth.
• Increased urination.
• Nocturia.
• Constipation.
• Hyperglycemia.
• Nausea.
• Fatigue.
• Dizziness.
• Orthostatic hypotension.
• Fever.
• Liver enzyme elevations.

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it may exacerbate dehydration or liver effects.
• Pregnancy - Not recommended during pregnancy unless clearly necessary, as animal studies show potential fetal harm.
• Breastfeeding - Discontinue breastfeeding or the drug, as it is unknown if it passes into breast milk and could harm the infant.
• Liver - Contraindicated in patients with underlying liver disease, including cirrhosis, due to risk of severe liver injury.
• Kidney - Use with caution in severe renal impairment; efficacy may be reduced. Not for use in anuric patients.
• Lung - Generally safe for patients with lung conditions; no specific contraindications known.

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