Acoxal 50mg Injection

About

Acoxal 50mg Injection contains Oxaliplatin, a platinum-based antineoplastic agent belonging to the alkylating class of chemotherapy drugs. It exerts its cytotoxic effects by forming DNA adducts, which are bulky lesions that interfere with DNA replication and transcription. This disruption ultimately leads to cell cycle arrest and programmed cell death (apoptosis) in rapidly dividing cancer cells. Oxaliplatin is particularly effective in the treatment of colorectal cancer, where it is often used in combination with fluoropyrimidines like 5-fluorouracil and leucovorin as part of regimens such as FOLFOX. Its distinct mechanism of action and demonstrated efficacy against certain platinum-resistant tumors make it a crucial component in various chemotherapy protocols for gastrointestinal malignancies. The drug is administered intravenously under strict medical supervision.

Uses

• Adjuvant treatment of stage III colon cancer
• Metastatic colorectal cancer
• Gastric cancer (off-label)
• Pancreatic cancer (off-label)

Directions For Use

Administered intravenously by a qualified healthcare professional. The dosage and infusion schedule are determined by the physician based on the patient's body surface area and treatment regimen.

Benefits

• Improves disease-free survival in colon cancer.
• Extends overall survival in metastatic colorectal cancer.
• Effective in combination chemotherapy regimens.
• Offers a treatment option for advanced gastrointestinal cancers.
• Has a distinct mechanism from other platinum agents.
• Can reduce tumor size and progression.

Side Effects

• Peripheral neuropathy (acute and chronic)
• Nausea and vomiting
• Diarrhea
• Fatigue
• Myelosuppression (anemia, leukopenia, thrombocytopenia)
• Stomatitis/mucositis
• Abdominal pain
• Allergic reactions (rash, dyspnea)
• Hiccups
• Elevated liver enzymes
• Hair thinning
• Taste disturbance

Safety Measures

• Alcohol - Avoid alcohol as it may worsen gastrointestinal side effects and potentially interact with other medications in the regimen.
• Pregnancy - Contraindicated in pregnancy due to significant risk of fetal harm. Patients of reproductive potential must use effective contraception during and for several months after treatment.
• Breastfeeding - Breastfeeding is not recommended during treatment and for a period after, as oxaliplatin may be excreted in breast milk and harm the infant.
• Liver - Use with caution in patients with pre-existing liver impairment. Liver function should be monitored, and dose adjustments may be considered based on severity.
• Kidney - Use with caution in patients with moderate to severe renal impairment. Dose reduction may be necessary, and kidney function should be closely monitored.
• Lung - Rarely, interstitial lung disease or pulmonary fibrosis can occur. Monitor for new or worsening respiratory symptoms like cough or dyspnea.

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