Acozolo 250mg Capsule

About

Acozolo is an effective antifungal medication belonging to the azole class, specifically designed to combat a wide range of fungal infections. Its primary mechanism of action involves inhibiting the fungal cytochrome P450-dependent enzyme lanosterol 14-alpha-demethylase. This enzyme is crucial for the biosynthesis of ergosterol, a vital component of the fungal cell membrane. By disrupting ergosterol synthesis, Acozolo impairs the structural integrity and function of the fungal cell membrane, leading to increased permeability and ultimately fungal cell death. This targeted action makes Acozolo highly effective against various systemic and superficial fungal pathogens, providing a crucial therapeutic option for patients suffering from persistent or severe fungal infections.

Uses

• Treatment of systemic candidiasis.
• Management of cryptococcal meningitis.
• Therapy for oropharyngeal and esophageal candidiasis.
• Treatment of vaginal candidiasis.

Directions For Use

Take orally, usually once daily, with or without food, as directed by your physician. Swallow the capsule whole with water.

Benefits

• Possesses broad-spectrum antifungal activity.
• Effective against various fungal pathogens.
• Offers good oral bioavailability for systemic action.
• Convenient once-daily dosing for patient adherence.
• Penetrates well into various body tissues and fluids.
• Can be used for both treatment and prophylaxis of fungal infections.

Side Effects

• Nausea, vomiting, and diarrhea
• Abdominal pain
• Headache
• Rash
• Elevated liver enzymes
• Dizziness
• Taste perversion
• QT prolongation (rare but serious)
• Alopecia (with long-term, high-dose use)
• Severe skin reactions (e.g., Stevens-Johnson syndrome)
• Adrenal insufficiency
• Hepatotoxicity

Safety Measures

• Alcohol - Avoid or significantly limit alcohol consumption during treatment due to the potential for increased liver strain and hepatotoxicity.
• Pregnancy - Generally avoided during pregnancy unless the potential benefits clearly outweigh the risks, as there is a potential for birth defects.
• Breastfeeding - Not recommended during breastfeeding as Acozolo passes into breast milk and may pose risks to the nursing infant.
• Liver - Use with caution in patients with pre-existing liver impairment. Close monitoring of liver function tests is essential, and dose adjustment may be required.
• Kidney - Dose adjustment may be necessary in patients with moderate to severe renal impairment. Monitor kidney function regularly.
• Lung - Generally considered safe for use in patients with lung conditions, but monitor for any new or worsening respiratory symptoms if underlying lung disease exists.

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