AMTAS 5 TAB 15 S

About

Amlodipine is a long-acting dihydropyridine calcium channel blocker widely used for the treatment of hypertension and various forms of angina pectoris. Its primary mechanism involves inhibiting the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle cells. This inhibition leads to peripheral arterial vasodilation, which effectively reduces peripheral vascular resistance and consequently lowers systemic blood pressure.

In the context of angina, amlodipine improves myocardial oxygen supply by dilating coronary arteries and reduces myocardial oxygen demand by decreasing afterload. Known for its sustained pharmacological action, amlodipine allows for once-daily dosing, providing consistent 24-hour blood pressure control and symptom relief. It is a well-established agent in cardiovascular medicine, contributing to the prevention of cardiovascular events and improving the quality of life for patients with chronic cardiovascular conditions.

Uses

• Essential hypertension
• Chronic stable angina
• Vasospastic angina (Prinzmetal's angina)
• Coronary artery disease

Directions For Use

Take one tablet orally once daily, with or without food, at approximately the same time each day, as directed by your doctor.

Benefits

• Effectively lowers high blood pressure.
• Reduces frequency and severity of angina attacks.
• Provides sustained 24-hour blood pressure control.
• Improves blood flow to the heart.
• Well-tolerated for long-term use.
• Reduces risk of cardiovascular events.

Side Effects

• Edema (swelling of ankles/feet)
• Headache
• Dizziness
• Flushing
• Fatigue
• Palpitations
• Nausea
• Abdominal pain
• Somnolence (drowsiness)
• Muscle cramps
• Gingival hyperplasia (gum overgrowth)
• Hypotension (low blood pressure)

Safety Measures

• Alcohol - Alcohol can enhance the blood pressure-lowering effect and may cause increased dizziness. Use with caution.
• Pregnancy - Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor.
• Breastfeeding - Amlodipine is excreted in human milk. Use with caution and only if clearly needed.
• Liver - Use with caution in patients with liver impairment; dose adjustment may be necessary.
• Kidney - Generally safe for use in patients with kidney conditions; no dose adjustment is typically required.
• Lung - No specific contraindications or precautions related to lung conditions.

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