ARKAPRES 100 TAB 10 TAB

About

Losartan is a highly selective angiotensin II receptor blocker (ARB) that functions by specifically blocking the binding of angiotensin II to the AT1 receptor, thereby inhibiting its potent vasoconstrictive and aldosterone-secreting effects. This targeted action results in effective vasodilation, a reduction in systemic vascular resistance, and a subsequent lowering of blood pressure. Losartan is a cornerstone medication for the treatment of essential hypertension and is particularly valuable for patients with type 2 diabetes and nephropathy, as it significantly slows the progression of kidney disease. Furthermore, it is indicated for reducing the risk of stroke in patients with hypertension and left ventricular hypertrophy. Its efficacy, coupled with a generally favorable side effect profile, including a lower incidence of cough compared to ACE inhibitors, makes it a preferred choice for many patients requiring long-term blood pressure management and cardiovascular protection.

Uses

• Treatment of essential hypertension.
• Reduction of stroke risk in hypertensive patients with left ventricular hypertrophy.
• Management of diabetic nephropathy in type 2 diabetes.
• Treatment of heart failure (off-label or specific indications).

Directions For Use

Take orally once daily, with or without food, as directed by your healthcare provider. Maintain consistent daily dosing.

Benefits

• Effective blood pressure control.
• Reduces risk of stroke.
• Protects kidney function in diabetic nephropathy.
• Well-tolerated with low incidence of cough.
• Provides cardiovascular protection.
• Once-daily dosing convenience.

Side Effects

• Dizziness
• Fatigue
• Hypotension
• Hyperkalemia (elevated potassium)
• Renal dysfunction (rare)
• Upper respiratory infection
• Diarrhea
• Back pain
• Muscle cramps
• Angioedema (rare but serious)
• Cough (less common than ACE inhibitors)
• Headache

Safety Measures

• Alcohol - Alcohol may increase the hypotensive effect of losartan; use with caution and avoid excessive intake.
• Pregnancy - Contraindicated during the second and third trimesters of pregnancy due to risk of fetal injury and death.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and could harm the infant.
• Liver - Use with caution in patients with hepatic impairment; a lower starting dose may be necessary.
• Kidney - Use with caution in patients with renal artery stenosis or severe renal impairment; monitor kidney function closely.
• Lung - No specific contraindications or dose adjustments related to lung conditions; generally well-tolerated.

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