ARNEY 100

About

Sacubitril/Valsartan is a novel combination medication classified as an angiotensin receptor-neprilysin inhibitor (ARNI), specifically designed for the management of chronic heart failure with reduced ejection fraction. This medication exerts its therapeutic effects through a dual mechanism: sacubitril inhibits neprilysin, an enzyme responsible for degrading natriuretic peptides and other vasoactive substances, thereby increasing their beneficial levels. Concurrently, valsartan, an angiotensin II type 1 receptor blocker, counteracts the detrimental effects of the renin-angiotensin-aldosterone system. This synergistic action leads to significant vasodilation, enhanced natriuresis, and a reduction in adverse cardiac remodeling. Clinically, Sacubitril/Valsartan has demonstrated superior efficacy in reducing cardiovascular mortality and heart failure hospitalizations, while also improving symptoms and physical limitations in affected patients, representing a significant advancement in heart failure treatment.

Uses

• Treatment of chronic heart failure with reduced ejection fraction.
• Reduction of cardiovascular death and heart failure hospitalization.
• Improvement of symptoms and physical limitations in heart failure.
• Management of symptomatic chronic heart failure.

Directions For Use

Take orally twice daily, as prescribed by your doctor, usually with or without food.

Benefits

• Significantly reduces risk of cardiovascular death.
• Lowers heart failure hospitalization rates.
• Improves symptoms and quality of life.
• Offers a novel dual mechanism of action.
• More effective than ACE inhibitors alone in certain patients.
• Well-tolerated in many patients.

Side Effects

• Hypotension (low blood pressure)
• Hyperkalemia (high potassium levels)
• Renal impairment
• Cough
• Dizziness
• Fatigue
• Nausea
• Diarrhea
• Angioedema (rare but serious swelling)
• Headache
• Syncope (fainting)
• Anemia

Safety Measures

• Alcohol - Alcohol can exacerbate hypotension; use with caution and avoid excessive intake.
• Pregnancy - Contraindicated during pregnancy due to risk of fetal injury or death. Use effective contraception.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk. Consult your doctor.
• Liver - Use with caution in patients with moderate hepatic impairment; not recommended in severe impairment.
• Kidney - May cause renal impairment; monitor kidney function regularly. Not recommended in severe renal failure.
• Lung - No specific contraindications related to lung conditions, but monitor for cough, a common side effect.

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