ARSENAM 10MG INJECTION VIAL

About

Arsenic trioxide is a unique antineoplastic agent specifically indicated for the treatment of acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia. Its multifaceted mechanism of action involves inducing apoptosis in APL cells through several pathways, including mitochondrial damage, activation of caspases, and the degradation of the pathognomonic PML-RARα fusion protein. Furthermore, it promotes the differentiation of leukemic promyelocytes into mature granulocytes, thereby reducing the malignant cell burden. Administered intravenously, arsenic trioxide has revolutionized APL treatment, demonstrating remarkable efficacy in achieving high rates of complete remission in both newly diagnosed and relapsed/refractory patients, often synergistically combined with all-trans retinoic acid (ATRA).

Uses

• Acute promyelocytic leukemia (APL)
• Relapsed/refractory APL
• Newly diagnosed APL (in combination)
• Other hematologic malignancies (off-label)

Directions For Use

Administered intravenously by a healthcare professional. Dosage and duration are determined by the physician based on the specific APL protocol.

Benefits

• Highly effective in inducing remission in APL.
• Can be used in both frontline and relapsed settings.
• Promotes differentiation and apoptosis of APL cells.
• Often used in combination with ATRA for enhanced efficacy.
• Reduces the risk of coagulopathy associated with APL.
• Contributes to improved survival rates in APL patients.

Side Effects

• QT interval prolongation
• Differentiation syndrome (APL differentiation syndrome)
• Fatigue
• Nausea and vomiting
• Diarrhea
• Peripheral neuropathy
• Headache
• Fever
• Edema
• Liver enzyme elevation
• Electrolyte disturbances (e.g., hypokalemia, hypomagnesemia)
• Cardiac arrhythmias

Safety Measures

• Alcohol - Avoid alcohol during treatment as it may exacerbate gastrointestinal side effects and potentially increase liver toxicity.
• Pregnancy - Arsenic trioxide is embryotoxic and teratogenic. It is contraindicated in pregnancy; effective contraception is essential for both male and female patients.
• Breastfeeding - Breastfeeding is contraindicated during arsenic trioxide therapy due to the potential for serious adverse effects in the infant.
• Liver - Use with caution in patients with hepatic impairment; monitor liver function tests regularly. Dose adjustments may be necessary.
• Kidney - Use with caution in patients with renal impairment; monitor kidney function tests regularly. Dose adjustments may be necessary.
• Lung - Differentiation syndrome can manifest with respiratory distress; monitor for new or worsening pulmonary symptoms and manage promptly.

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