Bufatas IV 60mg Injection

About

Bufatas IV 60mg Injection likely contains Busulfan, an alkylating antineoplastic agent primarily used in conditioning regimens before hematopoietic stem cell transplantation. Busulfan works by cross-linking DNA strands, which interferes with DNA replication and transcription, leading to cell cycle arrest and apoptosis. This action is particularly effective against rapidly dividing cells, including cancerous cells and bone marrow cells.

Its potent myelosuppressive effects are crucial for preparing the bone marrow for transplantation, eradicating existing malignant cells, and creating space for engraftment of new stem cells. It is a cornerstone in the treatment of certain leukemias and other hematological malignancies requiring transplant.

Uses

• Chronic Myeloid Leukemia (CML)
• Conditioning for stem cell transplant
• Polycythemia Vera
• Essential Thrombocythemia

Directions For Use

Administer intravenously under strict medical supervision by a qualified healthcare professional.

Benefits

• Effective in myeloablative conditioning
• Prepares bone marrow for transplant
• Reduces tumor burden in certain cancers
• Prolongs remission in hematological malignancies
• Established efficacy in CML treatment
• Available in IV formulation for precise dosing

Side Effects

• Severe myelosuppression
• Nausea
• Vomiting
• Mucositis
• Hepatotoxicity (veno-occlusive disease)
• Seizures
• Interstitial pneumonitis
• Alopecia
• Skin hyperpigmentation
• Diarrhea
• Fever
• Headache

Safety Measures

• Alcohol - Avoid alcohol due to potential for increased liver toxicity and gastrointestinal irritation.
• Pregnancy - Contraindicated; highly teratogenic and embryotoxic. Use effective contraception during and after treatment.
• Breastfeeding - Not recommended; drug is cytotoxic and may pass into breast milk, potentially harming the infant.
• Liver - Use with extreme caution; high risk of hepatotoxicity, including veno-occlusive disease. Monitor liver function closely.
• Kidney - Use with caution; monitor renal function closely, and dose adjustment may be needed in severe impairment.
• Lung - High risk of interstitial pneumonitis (busulfan lung); monitor respiratory function closely during and after treatment.

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