Ciclib 100mg Capsule

About

Ciclib 100mg Capsule is an oral, targeted therapeutic agent classified as a cyclin-dependent kinase (CDK) 4/6 inhibitor. It is primarily indicated for the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer. The mechanism of action involves the selective inhibition of CDK4 and CDK6, key enzymes that regulate cell cycle progression from the G1 phase to the S phase. By blocking the activity of these kinases, Ciclib prevents cancer cells from advancing through the cell cycle, thereby arresting their proliferation and inducing senescence or apoptosis. This targeted approach effectively slows tumor growth and progression. Ciclib is typically administered in combination with endocrine therapy, such as an aromatase inhibitor or fulvestrant, to enhance anti-tumor activity and improve clinical outcomes for patients with this specific subtype of breast cancer.

Uses

• Treatment of HR+, HER2- advanced or metastatic breast cancer.
• Used in combination with endocrine therapy (e.g., aromatase inhibitor, fulvestrant).
• First-line therapy for postmenopausal women with metastatic breast cancer.
• Second-line therapy for patients whose disease progressed on endocrine therapy.

Directions For Use

Take the capsule orally once daily with food, as prescribed by your doctor.

Swallow the capsule whole; do not chew, crush, or open it.

Benefits

• Significantly improves progression-free survival.
• Delays disease progression in advanced breast cancer.
• Offers a targeted treatment approach.
• Oral administration for patient convenience.
• Can be used in combination with existing therapies.
• May improve overall response rates.

Side Effects

• Neutropenia (low white blood cell count)
• Leukopenia (low total white blood cell count)
• Fatigue
• Nausea
• Diarrhea
• Stomatitis (mouth sores)
• Hair thinning (alopecia)
• Anemia
• Thrombocytopenia (low platelet count)
• Infections
• Elevated liver enzymes
• Interstitial lung disease/pneumonitis (rare)

Safety Measures

• Alcohol - No specific interaction, but excessive alcohol consumption should be avoided as it may exacerbate fatigue or liver-related side effects.
• Pregnancy - Ciclib is contraindicated in pregnancy due to potential fetal harm. Women of childbearing potential must use effective contraception during treatment and for a period after.
• Breastfeeding - Breastfeeding is not recommended during treatment with Ciclib and for a period after the last dose due to potential harm to the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary. Regular monitoring of liver function tests is essential.
• Kidney - Use with caution in patients with severe renal impairment; dose adjustments may be necessary.
• Lung - Monitor for signs and symptoms of interstitial lung disease or pneumonitis (e.g., hypoxia, cough, dyspnea); discontinue if severe.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.