Denosurel 120mg Injection

About

Denosurel 120mg Injection is a potent medication primarily used in oncology to manage bone-related complications. It contains an active ingredient that is a monoclonal antibody, specifically designed to target and inhibit RANKL (Receptor Activator of Nuclear factor Kappa-B Ligand). By blocking RANKL, it prevents its interaction with RANK on the surface of osteoclast precursors and mature osteoclasts, thereby inhibiting the formation, function, and survival of osteoclasts. This leads to a significant reduction in bone resorption, which is crucial in preventing skeletal-related events (SREs) in patients with bone metastases from solid tumors.

At this higher dose, Denosurel is also indicated for the treatment of giant cell tumor of bone in adults and adolescents with mature skeletons, where surgical resection is inappropriate. Its mechanism of action effectively reduces bone destruction, alleviates bone pain, and helps maintain skeletal integrity in advanced cancer settings. Administered subcutaneously, it offers a targeted approach to bone health management, providing significant benefits in improving patient quality of life and reducing the morbidity associated with bone metastases.

Uses

• Prevention of skeletal-related events in patients with bone metastases from solid tumors.
• Treatment of giant cell tumor of bone.
• Treatment of hypercalcemia of malignancy refractory to bisphosphonate therapy.
• Reduction of bone destruction in multiple myeloma.

Directions For Use

Administered subcutaneously by a healthcare professional, typically once every 4 weeks. Ensure adequate calcium and vitamin D intake.

Benefits

• Significantly reduces the risk of skeletal-related events.
• Effective in treating giant cell tumor of bone.
• Helps manage hypercalcemia of malignancy.
• Reduces bone pain associated with metastases.
• Convenient subcutaneous administration.
• Targeted action on bone resorption.

Side Effects

• Hypocalcemia (low calcium levels).
• Osteonecrosis of the jaw (ONJ).
• Atypical femoral fractures.
• Back pain.
• Musculoskeletal pain.
• Nausea and diarrhea.
• Fatigue and headache.
• Dyspnea (shortness of breath).
• Cellulitis.
• Allergic reactions.
• Constipation.
• Peripheral edema.

Safety Measures

• Alcohol - No known direct interaction, but general health considerations apply, especially for cancer patients.
• Pregnancy - Contraindicated due to potential for fetal harm; effective contraception is required during treatment.
• Breastfeeding - Not recommended; potential for excretion in breast milk and harm to the infant.
• Liver - No dose adjustment needed; generally considered safe for patients with liver conditions.
• Kidney - Use with caution in severe renal impairment; monitor calcium levels closely and ensure hydration.
• Lung - No specific contraindication, but monitor for dyspnea, especially in patients with pre-existing lung conditions.

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