Evenity Injection

About

Evenity (Romosozumab) is a novel bone-forming agent specifically designed for the treatment of osteoporosis in postmenopausal women at high risk of fracture. Its unique dual mechanism of action involves both increasing bone formation and, to a lesser extent, decreasing bone resorption. Romosozumab achieves this by inhibiting sclerostin, a protein produced by osteocytes that normally suppresses bone formation. By blocking sclerostin, it stimulates osteoblast activity, leading to a rapid and substantial increase in bone mineral density. This anabolic effect helps to rebuild bone structure and significantly reduce the risk of vertebral and non-vertebral fractures, offering a distinct therapeutic option for patients with severe osteoporosis who require rapid bone strengthening.

Uses

• Postmenopausal osteoporosis
• High risk of fracture
• Severe osteoporosis
• Patients intolerant to other therapies

Directions For Use

Administer via subcutaneous injection once monthly for 12 doses, as directed by your physician. Ensure proper injection technique.

Benefits

• Rapid increase in bone mineral density
• Reduces risk of vertebral fractures
• Reduces risk of non-vertebral fractures
• Unique dual action (increases bone formation, decreases resorption)
• Offers monthly dosing convenience
• Effective in severe osteoporosis

Side Effects

• Joint pain (arthralgia)
• Headache
• Muscle spasms
• Injection site reactions
• Hypocalcemia
• Atypical femoral fractures
• Osteonecrosis of the jaw
• Cardiovascular events (e.g., myocardial infarction, stroke)
• Allergic reactions
• Back pain
• Neck pain
• Insomnia

Safety Measures

• Alcohol - No specific interaction, but excessive alcohol can negatively impact bone health.
• Pregnancy - Not indicated for use in women of childbearing potential; contraindicated in pregnancy.
• Breastfeeding - Not recommended during breastfeeding due to potential risks to the infant.
• Liver - No specific dose adjustment needed for liver impairment.
• Kidney - Use with caution in severe kidney impairment; monitor calcium levels closely.
• Lung - No specific precautions related to lung conditions.

Disclaimer

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