Ustekirel 45mg Injection

About

Ustekinumab is a human monoclonal antibody that selectively binds to the p40 protein subunit, common to both interleukin-12 (IL-12) and interleukin-23 (IL-23) cytokines. By inhibiting these cytokines, which are naturally occurring proteins involved in inflammatory and immune responses, ustekinumab helps to reduce inflammation and modulate the immune system. It is used in the treatment of several chronic inflammatory conditions where these cytokines play a key role in the pathogenesis, including moderate to severe plaque psoriasis, psoriatic arthritis, and moderate to severe Crohn's disease and ulcerative colitis. Its mechanism of action targets specific pathways, offering a more focused approach to managing these complex autoimmune diseases by interrupting the inflammatory cascade. This targeted therapy aims to provide significant symptom relief and improve the quality of life for patients who have not responded adequately to conventional treatments.

Uses

• Moderate to severe plaque psoriasis
• Active psoriatic arthritis
• Moderate to severe Crohn's disease
• Moderate to severe ulcerative colitis

Directions For Use

Administered via subcutaneous injection by a healthcare professional. Follow the prescribed dosage and schedule strictly.

Benefits

• Reduces skin lesions in psoriasis
• Alleviates joint pain and swelling in psoriatic arthritis
• Induces and maintains remission in Crohn's disease
• Improves symptoms and mucosal healing in ulcerative colitis
• Offers long-term disease control
• Generally well-tolerated with targeted action

Side Effects

• Upper respiratory tract infection
• Headache
• Fatigue
• Injection site reactions (redness, pain)
• Nausea
• Diarrhea
• Pharyngolaryngeal pain
• Dizziness
• Urinary tract infection
• Sinusitis
• Bronchitis
• Vaginal yeast infection

Safety Measures

• Alcohol - No specific contraindication, but excessive alcohol can worsen underlying inflammatory conditions or liver function.
• Pregnancy - Use only if clearly needed; potential risks to the fetus cannot be excluded. Consult a doctor.
• Breastfeeding - Small amounts may pass into breast milk. Weigh benefits against potential risks; consult a healthcare provider.
• Liver - Use with caution in patients with pre-existing liver conditions. Monitor liver function tests.
• Kidney - No specific dose adjustment needed for mild to moderate renal impairment. Use with caution in severe cases.
• Lung - Use with caution in patients with a history of chronic or recurrent infections, including tuberculosis.

Disclaimer

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