Prolia 60mg Injection

About

Denosumab is a human monoclonal antibody that specifically targets and binds to RANK Ligand (RANKL), a protein essential for the formation, function, and survival of osteoclasts. By inhibiting RANKL, denosumab prevents osteoclast activation and differentiation, thereby reducing bone resorption and increasing bone mineral density. This mechanism makes it highly effective in treating postmenopausal osteoporosis, increasing bone mass in men with osteoporosis, and managing bone loss associated with hormone ablation therapy for prostate or breast cancer.

It is also used to prevent skeletal-related events (SREs) such as pathological fractures, spinal cord compression, or the need for radiation or surgery to bone, in patients with bone metastases from solid tumors. Administered subcutaneously, denosumab provides a sustained reduction in bone turnover markers, offering a significant therapeutic option for various bone-related conditions.

Uses

• Treatment of postmenopausal osteoporosis
• Increased bone mass in men with osteoporosis
• Bone loss associated with hormone ablation therapy for prostate or breast cancer
• Prevention of skeletal-related events in cancer patients with bone metastases

Directions For Use

Administered via subcutaneous injection by a healthcare professional. Follow the prescribed dosing schedule, typically every six months for osteoporosis or more frequently for cancer-related indications.

Benefits

• Significantly increases bone mineral density
• Reduces the risk of vertebral, non-vertebral, and hip fractures
• Potently inhibits osteoclast activity and bone resorption
• Effective in treating various forms of osteoporosis
• Prevents skeletal-related events in cancer patients with bone metastases
• Convenient subcutaneous administration, typically every six months

Side Effects

• Back pain and musculoskeletal pain
• Pain in extremities
• Hypercholesterolemia
• Cystitis (bladder infection)
• Hypocalcemia (low blood calcium), especially with pre-existing conditions
• Skin infections (e.g., cellulitis)
• Osteonecrosis of the jaw (ONJ) (rare but serious)
• Atypical femoral fractures (rare)
• Constipation or diarrhea
• Rash and eczema
• Fatigue
• Headache

Safety Measures

• Alcohol - No direct interaction with alcohol is known, but excessive alcohol intake can negatively impact bone health. Moderate consumption is generally advised.
• Pregnancy - Not recommended during pregnancy due to potential harm to the fetus. Use effective contraception during and for at least 5 months after the last dose.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if it passes into breast milk. Consult a doctor for alternatives.
• Liver - No specific dose adjustment is required for patients with liver impairment. Use with caution and monitor for any adverse effects.
• Kidney - Use with caution in patients with severe kidney impairment (CrCl < 30 mL/min) or on dialysis, as they are at higher risk of hypocalcemia. Calcium and vitamin D supplementation is crucial.
• Lung - No specific contraindications or dose adjustments related to lung conditions. However, general health status should be considered.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.