Elpag 50mg Tablet

About

Elpag 50mg Tablet contains eltrombopag, an oral thrombopoietin receptor agonist. It works by stimulating the proliferation and differentiation of megakaryocytes in the bone marrow, leading to an increased production of platelets. This mechanism helps to raise and maintain platelet counts in patients with various conditions characterized by thrombocytopenia, thereby reducing the risk of bleeding. Its action mimics that of endogenous thrombopoietin, binding to and activating the thrombopoietin receptor. This targeted approach makes it effective in managing low platelet levels where conventional treatments may be insufficient or contraindicated.

The drug is crucial for patients who require sustained elevation of platelet counts to prevent hemorrhagic events. By increasing platelet production, Elpag helps to improve the patient's ability to form clots and reduces the need for platelet transfusions, significantly enhancing their quality of life and reducing the morbidity associated with severe thrombocytopenia. Regular monitoring of platelet counts and liver function is essential during treatment to ensure optimal efficacy and safety, with dosage adjusted based on individual response and platelet levels.

Uses

• Chronic immune thrombocytopenia (ITP)
• Severe aplastic anemia (SAA)
• Thrombocytopenia in chronic hepatitis C
• Refractory ITP in adults

Directions For Use

Take orally once daily on an empty stomach, at least 2 hours before or 4 hours after calcium-containing products.

Benefits

• Increases platelet count effectively
• Reduces the risk of bleeding episodes
• Decreases the need for platelet transfusions
• Improves quality of life for thrombocytopenic patients
• Convenient oral administration
• Effective in various underlying conditions causing low platelets

Side Effects

• Nausea
• Diarrhea
• Abdominal pain
• Fatigue
• Headache
• Muscle pain
• Increased liver enzymes
• Thromboembolic events
• Cataracts
• Bone marrow fibrosis
• Rash
• Anemia

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate liver side effects.
• Pregnancy - Not recommended during pregnancy unless clearly necessary; potential fetal harm.
• Breastfeeding - Advise against breastfeeding due to potential for serious adverse reactions in the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustment may be required.
• Kidney - Generally safe in renal impairment, but monitor for adverse effects.
• Lung - No specific contraindications related to lung conditions, but monitor overall health.

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