Eltoplate 25mg Tablet

About

Eltrombopag is a thrombopoietin receptor agonist that stimulates the proliferation and differentiation of megakaryocytes, leading to an increase in platelet production. It is orally active and mimics the effects of endogenous thrombopoietin, a hormone that regulates platelet production. This mechanism helps to elevate and maintain platelet counts in patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to other treatments, or in those with severe aplastic anemia (SAA) who are refractory to immunosuppressive therapy. The drug binds to the thrombopoietin receptor on megakaryocytes, initiating intracellular signaling pathways that promote the growth and maturation of platelet precursor cells in the bone marrow.

Uses

• Treatment of chronic immune thrombocytopenia (ITP).
• Management of severe aplastic anemia (SAA).
• Treatment of thrombocytopenia in patients with chronic hepatitis C.
• Prevention of bleeding episodes due to low platelet counts.

Directions For Use

Take this tablet orally as directed by your physician, usually once daily on an empty stomach. Avoid taking with dairy products or antacids.

Benefits

• Significantly increases platelet counts.
• Reduces the risk of bleeding episodes.
• Offers an oral treatment option for thrombocytopenia.
• Improves quality of life for patients with chronic ITP.
• Effective in refractory severe aplastic anemia.
• Allows for dose adjustments based on platelet response.

Side Effects

• Nausea
• Diarrhea
• Abdominal pain
• Fatigue
• Headache
• Muscle pain
• Joint pain
• Increased liver enzymes
• Cataracts
• Thromboembolic events
• Bone marrow reticulin formation
• Skin rash

Safety Measures

• Alcohol - Alcohol consumption should be limited or avoided as it may exacerbate liver enzyme elevations, a potential side effect of this medication.
• Pregnancy - This medication is generally not recommended during pregnancy unless the potential benefits outweigh the risks, as animal studies have shown adverse effects on fetal development.
• Breastfeeding - It is advised to discontinue breastfeeding during treatment with this medication due to the potential for serious adverse reactions in the breastfed infant.
• Liver - Use with caution in patients with pre-existing liver impairment; dose adjustments may be necessary, and regular monitoring of liver function tests is crucial.
• Kidney - No specific dose adjustment is typically required for patients with mild to moderate renal impairment, but caution is advised in severe cases.
• Lung - No specific contraindications or precautions related to lung conditions are generally noted for this medication.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.