Glycinorm Total 60

About

Glycinorm Total 60 is a combination oral anti-diabetic medication containing Gliclazide (a sulfonylurea) and Metformin (a biguanide), used to improve glycemic control in adults with type 2 diabetes mellitus. Gliclazide works by stimulating insulin secretion from the pancreatic beta cells, particularly in the presence of glucose. Metformin, on the other hand, primarily reduces hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.

This dual mechanism of action provides comprehensive blood sugar control, addressing both insulin secretion and insulin resistance. It is typically prescribed when diet, exercise, and monotherapy with either Gliclazide or Metformin alone do not achieve adequate glycemic targets. Regular monitoring of blood glucose, HbA1c, and kidney function is essential to ensure efficacy and safety, particularly to detect potential side effects like lactic acidosis associated with metformin.

Uses

• Management of type 2 diabetes mellitus.
• Improvement of glycemic control.
• When diet and exercise alone are insufficient.
• When monotherapy with Gliclazide or Metformin is inadequate.

Directions For Use

Take orally with meals, usually once or twice daily, as directed by your healthcare provider. Swallow tablets whole.

Benefits

• Provides comprehensive blood sugar control.
• Reduces both fasting and post-meal glucose levels.
• Lowers HbA1c effectively.
• Combines two complementary mechanisms of action.
• May lead to modest weight loss (Metformin effect).
• Reduces the risk of diabetes-related complications.

Side Effects

• Hypoglycemia (low blood sugar)
• Gastrointestinal upset (nausea, vomiting, diarrhea)
• Abdominal pain
• Metallic taste in mouth
• Headache
• Dizziness
• Skin rash
• Weight gain (Gliclazide effect)
• Vitamin B12 deficiency (long-term Metformin)
• Lactic acidosis (rare, serious with Metformin)
• Liver enzyme elevations (rare)
• Blood dyscrasias (rare with Gliclazide)

Safety Measures

• Alcohol - Avoid excessive alcohol intake as it can increase the risk of hypoglycemia and lactic acidosis, especially with Metformin.
• Pregnancy - Not recommended during pregnancy; insulin therapy is generally preferred for gestational diabetes.
• Breastfeeding - Avoid during breastfeeding as both components may pass into breast milk.
• Liver - Use with extreme caution in patients with liver impairment; Metformin is contraindicated in severe liver disease due to lactic acidosis risk.
• Kidney - Contraindicated in severe kidney impairment (eGFR <30 mL/min/1.73m²) due to increased risk of lactic acidosis with Metformin. Dose adjustment needed for moderate impairment.
• Lung - Use with caution in severe acute or chronic lung disease, as conditions causing hypoxia can increase lactic acidosis risk with Metformin.

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