Lanvis 40mg Tablet

About

Lanvis 40mg Tablet contains Thioguanine, a purine analogue antimetabolite that functions as a potent cytotoxic agent. It is primarily utilized in the treatment of various acute and chronic leukemias. Thioguanine is a prodrug that undergoes intracellular conversion into active metabolites, which are subsequently incorporated into both DNA and RNA. This incorporation profoundly disrupts nucleic acid synthesis and function, leading to cell cycle arrest and ultimately inducing apoptosis, particularly in rapidly proliferating malignant cells. Its mechanism of action specifically interferes with the de novo synthesis of purine nucleotides, which are essential building blocks for DNA and RNA, thereby inhibiting the division and growth of cancer cells. Lanvis is often used as a critical component within multi-drug combination chemotherapy regimens to achieve optimal therapeutic outcomes.

Uses

• Acute myeloid leukemia (AML)
• Acute lymphoblastic leukemia (ALL)
• Chronic myeloid leukemia (CML)
• Non-Hodgkin's lymphoma (less common)

Directions For Use

Take the tablet orally as directed by your oncologist, usually once daily. It can be taken with or without food.

Benefits

• Effective in treating various types of leukemia.
• Oral formulation offers convenience for long-term treatment.
• Can be used in combination with other chemotherapeutic agents.
• Targets rapidly dividing cancer cells.
• Contributes to disease remission and improved survival rates.
• Well-established efficacy in hematologic oncology.

Side Effects

• Myelosuppression (low blood counts)
• Nausea and vomiting
• Diarrhea
• Oral mucositis
• Hepatotoxicity (liver damage)
• Pancreatitis (rare)
• Skin rash
• Anorexia
• Fatigue
• Hyperuricemia
• Alopecia (hair thinning)
• Venocclusive disease of the liver (rare, serious)

Safety Measures

• Alcohol - Avoid alcohol as it may increase the risk of hepatotoxicity and exacerbate gastrointestinal side effects.
• Pregnancy - Contraindicated in pregnancy due to significant teratogenic and embryotoxic risks. Effective contraception is mandatory during and after treatment.
• Breastfeeding - Not recommended during breastfeeding as the drug is likely excreted in breast milk and could cause serious adverse effects in the infant.
• Liver - Use with extreme caution in patients with hepatic impairment; dose adjustments are crucial, and regular monitoring of liver function is essential due to hepatotoxicity risk.
• Kidney - Use with caution in patients with renal impairment; dose adjustments may be necessary to prevent drug accumulation and increased toxicity.
• Lung - Rarely, interstitial pneumonitis has been reported; monitor for new or worsening respiratory symptoms.

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