Ltromb 25mg Tablet

About

Eltrombopag is a thrombopoietin receptor agonist (TPO-RA) that stimulates the proliferation and differentiation of megakaryocytes, the precursor cells to platelets, in the bone marrow. By binding to and activating the thrombopoietin receptor (c-Mpl), eltrombopag mimics the action of endogenous thrombopoietin, leading to an increase in platelet production. This mechanism is crucial for patients suffering from conditions characterized by insufficient platelet counts, where the body's natural ability to produce platelets is compromised.

This medication is administered orally and is primarily used to treat chronic immune thrombocytopenia (ITP) in patients who have had an insufficient response to other treatments, such as corticosteroids or immunoglobulins. It is also indicated for severe aplastic anemia (SAA) and chronic hepatitis C-associated thrombocytopenia. Eltrombopag helps to raise and maintain platelet counts above a critical threshold, thereby reducing the risk of bleeding events and improving the quality of life for affected individuals. Regular monitoring of platelet counts and liver function is essential during treatment.

Uses

• Treatment of chronic immune thrombocytopenia (ITP).
• Management of severe aplastic anemia (SAA).
• Treatment of chronic hepatitis C-associated thrombocytopenia.
• Prevention of bleeding in thrombocytopenic patients.

Directions For Use

Take orally once daily on an empty stomach, at least 2 hours before or 4 hours after calcium-containing foods, dairy products, or antacids.

Benefits

• Significantly increases platelet counts.
• Reduces the risk of bleeding events.
• Improves quality of life for thrombocytopenic patients.
• Effective in chronic ITP, SAA, and hepatitis C-related thrombocytopenia.
• Oral administration for convenience.
• Offers an alternative for patients unresponsive to other therapies.

Side Effects

• Nausea
• Diarrhea
• Upper respiratory tract infection
• Abdominal pain
• Fatigue
• Headache
• Cough
• Fever
• Increased liver enzymes
• Thromboembolic events (blood clots)
• Cataracts
• Bone marrow changes

Safety Measures

• Alcohol - Avoid or limit alcohol, especially with liver conditions, as it may exacerbate liver toxicity.
• Pregnancy - Not recommended during pregnancy; potential for fetal harm; use effective contraception.
• Breastfeeding - Avoid during breastfeeding; potential for serious adverse reactions in the infant.
• Liver - Use with caution and dose adjustment in liver impairment; monitor liver function closely.
• Kidney - No dose adjustment typically needed for renal impairment; monitor kidney function.
• Lung - No direct lung effects; however, monitor for any new or worsening respiratory symptoms.

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