Lucaparib 300mg Tablet

About

Lucaparib 300mg Tablet is a targeted anticancer agent belonging to the class of poly (ADP-ribose) polymerase (PARP) inhibitors. It works by blocking the activity of PARP enzymes, which are crucial for DNA repair in cells. In cancer cells with existing DNA repair defects, such as those with BRCA1/2 mutations or other homologous recombination deficiencies (HRD), PARP inhibition leads to an accumulation of DNA damage, ultimately resulting in synthetic lethality and cancer cell death.

This mechanism makes Lucaparib particularly effective in treating certain types of cancers that rely heavily on PARP-mediated DNA repair pathways. It represents a significant advancement in precision oncology, offering a targeted approach for patients with specific genetic profiles. The oral administration provides a convenient and less invasive treatment option, allowing for long-term maintenance therapy and improved patient adherence, thereby enhancing the overall management of advanced malignancies.

Uses

• Treatment of advanced ovarian cancer
• Management of HER2-negative metastatic breast cancer
• Treatment of metastatic castration-resistant prostate cancer
• Maintenance therapy for pancreatic cancer

Directions For Use

Take orally twice daily with or without food, as prescribed by your oncologist. Swallow the tablets whole; do not crush, chew, or split them.

Benefits

• Targets specific DNA repair pathways in cancer cells
• Effective in cancers with BRCA mutations or HRD
• Improves progression-free survival
• Extends remission periods
• Oral administration for patient convenience
• Reduces the risk of cancer recurrence

Side Effects

• Nausea
• Fatigue
• Anemia
• Vomiting
• Diarrhea
• Abdominal pain
• Decreased appetite
• Headache
• Dysgeusia (taste disturbance)
• Myelosuppression (bone marrow suppression)
• Rash
• Stomatitis

Safety Measures

• Alcohol - No direct interaction with alcohol, but moderation is generally advised. Consult your doctor regarding alcohol consumption.
• Pregnancy - Contraindicated during pregnancy as it can cause fetal harm. Effective contraception should be used during and for a period after treatment.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if the drug is excreted in breast milk and could harm the infant.
• Liver - Use with caution in patients with liver impairment. Liver function should be monitored regularly by your physician.
• Kidney - Use with caution in patients with kidney conditions. Dose adjustments may be necessary based on renal function.
• Lung - Monitor for symptoms of pneumonitis (e.g., cough, dyspnea). Use with caution in patients with pre-existing lung conditions.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.