Mistaurin 25mg Capsule

About

Mistaurin 25mg Capsule is a highly specific targeted therapy, functioning as a potent tyrosine kinase inhibitor (TKI). Its primary action is to selectively inhibit the Bcr-Abl fusion protein, which is the defining molecular abnormality and the key oncogenic driver in Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML). By blocking the aberrant kinase activity of Bcr-Abl, Mistaurin effectively disrupts the downstream signaling pathways that promote uncontrolled proliferation and survival of CML cells. This targeted inhibition leads to a significant reduction in the malignant cell population, normalization of peripheral blood cell counts, and the induction of deep cytogenetic and molecular remissions. It is indicated for the treatment of newly diagnosed Ph+ CML in the chronic phase, and for Ph+ CML in chronic or accelerated phase in adult patients who have demonstrated resistance or intolerance to previous TKI therapies, providing a critical therapeutic option.

Uses

• Newly diagnosed Ph+ CML (chronic phase)
• Ph+ CML (chronic or accelerated phase)
• CML resistant to prior TKI therapy
• CML intolerant to prior TKI therapy

Directions For Use

Take orally twice daily on an empty stomach, at least 2 hours after and 1 hour before food. Swallow capsules whole.

Benefits

• Highly effective in Ph+ CML.
• Induces deep molecular responses.
• Improves progression-free and overall survival.
• Oral administration for convenience.
• Targets the underlying cause of CML.
• Option for resistant/intolerant patients.

Side Effects

• Myelosuppression (neutropenia, thrombocytopenia)
• Nausea and vomiting
• Diarrhea
• Fatigue
• Headache
• Rash
• Elevated liver enzymes
• Fluid retention (edema)
• Muscle pain
• QT prolongation (cardiac)
• Pancreatitis
• Hyperglycemia

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may increase the risk of liver toxicity or gastrointestinal upset.
• Pregnancy - Contraindicated in pregnancy due to potential fetal harm; use effective contraception during treatment and for a period after.
• Breastfeeding - Advise against breastfeeding due to the potential for serious adverse reactions in breastfed infants.
• Liver - Use with caution in patients with hepatic impairment; dose adjustment may be necessary.
• Kidney - Use with caution in patients with renal impairment; monitor kidney function closely.
• Lung - Monitor for new or worsening pulmonary symptoms, including pleural effusion or interstitial lung disease.

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