NULONG TRIO 40 TAB

About

NULONG TRIO 40 TAB is a sophisticated fixed-dose combination medication engineered for the comprehensive management of essential hypertension, particularly in individuals requiring multiple pharmacological agents to achieve adequate blood pressure control. This formulation integrates Telmisartan, an angiotensin II receptor blocker (ARB); Amlodipine, a dihydropyridine calcium channel blocker; and Hydrochlorothiazide, a thiazide diuretic. Telmisartan provides sustained blockade of the AT1 receptor, effectively counteracting the vasoconstrictive and aldosterone-releasing effects of angiotensin II. Amlodipine induces peripheral vasodilation by inhibiting calcium influx into vascular smooth muscle cells, further lowering systemic vascular resistance. Hydrochlorothiazide enhances the renal excretion of sodium and water, thereby reducing extracellular fluid volume and blood pressure. This powerful triple action addresses diverse pathophysiological mechanisms underlying hypertension, leading to significant and sustained reductions in blood pressure and contributing to improved cardiovascular outcomes. It offers a convenient once-daily regimen for enhanced patient adherence.

Uses

• Treatment of essential hypertension.
• Management of severe or resistant hypertension.
• Reduction of cardiovascular risk in high-risk patients.
• When blood pressure is not controlled by monotherapy or dual therapy.

Directions For Use

Take one tablet orally once daily, with or without food, as prescribed by your healthcare provider.

Benefits

• Comprehensive and potent blood pressure reduction.
• Targets multiple pathways of hypertension.
• Reduces the risk of major cardiovascular events.
• Convenient once-daily dosing regimen.
• Effective for patients with resistant hypertension.
• May help mitigate Amlodipine-induced peripheral edema.

Side Effects

• Dizziness
• Headache
• Peripheral edema
• Fatigue
• Nausea
• Hypotension
• Hyperkalemia (Telmisartan)
• Hypokalemia (Hydrochlorothiazide)
• Muscle cramps
• Increased urination
• Upper respiratory tract infection
• Gout exacerbation (Hydrochlorothiazide)

Safety Measures

• Alcohol - Avoid alcohol consumption as it can intensify hypotensive effects and increase the risk of dizziness.
• Pregnancy - Contraindicated during pregnancy, especially in the second and third trimesters, due to fetal toxicity risks.
• Breastfeeding - Not recommended; components may be excreted in breast milk and could harm the nursing infant.
• Liver - Use with caution in patients with severe hepatic impairment; dose adjustment may be necessary.
• Kidney - Contraindicated in anuria; use with caution and monitor function in severe renal impairment.
• Lung - Generally safe for use; however, monitor for any unusual respiratory symptoms, especially in susceptible individuals.

Disclaimer

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