PENTASA SUPPOSITORIES TAB 4X7

About

Pentasa Suppositories deliver mesalazine (mesalamine), an aminosalicylate anti-inflammatory agent, directly to the site of inflammation in the rectum and distal colon. This formulation is specifically designed for the localized treatment of mild to moderate ulcerative colitis, particularly proctitis, where inflammation is confined to the rectum. Mesalazine works by inhibiting various inflammatory mediators, including prostaglandins and leukotrienes, and by scavenging free radicals within the bowel lumen. Its topical action minimizes systemic absorption, which is advantageous for reducing systemic side effects while effectively targeting the inflamed mucosa. This localized therapeutic approach helps to alleviate symptoms such as rectal bleeding, urgency, and discomfort, promoting healing and maintaining remission in affected patients.

Uses

• Treatment of mild to moderate ulcerative proctitis.
• Maintenance of remission in ulcerative proctitis.
• Reduction of inflammation in the rectum.
• Alleviation of rectal bleeding and urgency.

Directions For Use

Insert one suppository rectally, usually once or twice daily, as directed by your physician. Ensure proper hygiene before and after use.

Benefits

• Localized anti-inflammatory action.
• Effective for rectal inflammation.
• Reduces rectal bleeding and urgency.
• Helps maintain remission.
• Minimizes systemic side effects.
• Improves quality of life for proctitis patients.

Side Effects

• Rectal discomfort or irritation.
• Headache.
• Nausea.
• Abdominal pain.
• Diarrhea.
• Flatulence.
• Dizziness.
• Rash.
• Fever.
• Pancreatitis (rare).
• Myocarditis/pericarditis (rare).
• Nephrotoxicity (rare).

Safety Measures

• Alcohol - No specific interaction with alcohol is generally noted. However, alcohol can sometimes exacerbate gastrointestinal symptoms in IBD patients.
• Pregnancy - Use with caution during pregnancy. While generally considered low risk, consult a doctor to weigh potential benefits against risks.
• Breastfeeding - Mesalazine is excreted in breast milk. Use with caution, and monitor the infant for diarrhea. Consult a doctor.
• Liver - Use with caution in patients with impaired liver function. Regular monitoring of liver enzymes may be advised.
• Kidney - Use with caution in patients with impaired renal function. Regular monitoring of renal function is recommended, especially with long-term use.
• Lung - Rarely, mesalazine can cause hypersensitivity reactions affecting the lungs (e.g., eosinophilic pneumonia). Use with caution in patients with pre-existing lung conditions.

Disclaimer

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